BLOC1S1 and MTA1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		BLOC1S1	MTA1
Description		biogenesis of lysosomal organelles complex 1 subunit 1	metastasis associated 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Mitochondrial Intermembrane Space Mitochondrial Matrix Lysosomal Membrane Cytosol BLOC-1 Complex BORC Complex Axon Cytoplasm	Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol Microtubule NuRD Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Repressing Transcription Factor Binding Chromatin Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Deacetylase Binding
	Biological Process	Anterograde Axonal Transport Aerobic Respiration Endosomal Transport Peptidyl-lysine Acetylation Neuron Projection Development Lysosome Localization Melanosome Organization Anterograde Synaptic Vesicle Transport Platelet Dense Granule Organization	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Signal Transduction Response To Ionizing Radiation Histone Deacetylation Circadian Regulation Of Gene Expression Regulation Of Gene Expression, Epigenetic Entrainment Of Circadian Clock By Photoperiod Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Locomotor Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Autoubiquitination
Pathways		Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	HDACs deacetylate histones SUMOylation of transcription factors ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression RNA Polymerase I Transcription Initiation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Potential therapeutics for SARS
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Heel bone mineral density ( 30598549)
Interacting Genes		18 interacting genes: APP BLOC1S2 BLOC1S3 BLOC1S4 BLOC1S5 BLOC1S6 DCTN2 FBXO44 HGS MAGEB4 MTA1 NOTCH1 PBX2 PELP1 PTN SNAPC5 SNAPIN USHBP1	45 interacting genes: BCL11A BLOC1S1 CCNH CSNK1G2 CYSRT1 DDX18 DYNLL1 E2F1 ERCC6 ESR1 FHL3 GPR183 GRB2 H3-4 HDAC1 HDAC2 HIF1A ITGB3BP JUN KHDRBS2 KPNA4 KRT31 KRT40 KRTAP10-8 LMO4 LRRK2 LZTS2 MAGEA11 MBD3L2 MNAT1 NACC2 NBPF19 NELFCD NOTCH2NLA PICK1 PLEKHG4 RBBP4 SAT1 SH3GL1 SH3GLB1 SUMO2 TEX11 TP53 TRIM25 UBE2I
Entrez ID		2647	9112
HPRD ID		03263	04633
Ensembl ID		ENSG00000135441	ENSG00000182979
Uniprot IDs		P78537	Q13330 Q9BRL8
PDB IDs			4BKX 4PBY 4PBZ 4PC0 5FXY 5ICN 6G16
Enriched GO Terms of Interacting Partners?
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