MYCBP and ROBO1

Data Source:
BioGRID (two hybrid)

		MYCBP	ROBO1
Description		MYC binding protein	roundabout guidance receptor 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Binding Axon Guidance Receptor Activity LRR Domain Binding Identical Protein Binding
	Biological Process	Regulation Of Transcription, DNA-templated Spermatogenesis Positive Regulation Of Transcription, DNA-templated	Cell Migration Involved In Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Endocardial Cushion Formation Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Nervous System Development Axon Guidance Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Axon Midline Choice Point Recognition Chemorepulsion Involved In Postnatal Olfactory Bulb Interneuron Migration Negative Regulation Of Cell Migration Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Positive Regulation Of Rho Protein Signal Transduction Roundabout Signaling Pathway Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Aorta Development Positive Regulation Of MAP Kinase Activity Positive Regulation Of Axonogenesis Negative Regulation Of Negative Chemotaxis Ventricular Septum Morphogenesis Negative Regulation Of Chemokine-mediated Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Signaling Pathway
Pathways			Netrin-1 signaling Signaling by ROBO receptors Signaling by ROBO receptors Activation of RAC1 Regulation of commissural axon pathfinding by SLIT and ROBO Regulation of commissural axon pathfinding by SLIT and ROBO Inactivation of CDC42 and RAC1 Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling SLIT2:ROBO1 increases RHOA activity Regulation of cortical dendrite branching Regulation of expression of SLITs and ROBOs Regulation of expression of SLITs and ROBOs
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Blood protein levels ( 28240269) Menopause (age at onset) ( 26414677)	Adult body size ( 32376654) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Carotid plaque burden ( 28282560) Craniofacial microsomia ( 26853712) Diverticular disease ( 30177863) Excessive daytime sleepiness ( 27992416) Facial emotion recognition ( 28608620) Facial emotion recognition (fearful faces) ( 28608620) Glomerular filtration rate in chronic kidney disease ( 26420894) Liver enzyme levels (aspartate transaminase) ( 24124411) Metabolite levels ( 23823483) Moderate-to-late spontaneous preterm birth ( 31194736) Nose size ( 27182965) Protein quantitative trait loci ( 18464913) Refractive error ( 32231278) Schizophrenia ( 30285260) Staphylococcus aureus nasal carriage (intermittent) ( 26569114) Takayasu arteritis ( 25604533) Visceral adipose tissue ( 26480920)
Interacting Genes		16 interacting genes: AKAP1 ARHGEF40 CFAP91 CFL1 COPS6 CPNE1 CPNE2 CPNE4 DISP3 ERBB3 GDF9 MYC MYCBPAP PTN SSRP1 UBC	9 interacting genes: ABL1 MAGEB6 MAPK14 ROBO2 SLIT1 SLIT2 SRGAP1 SRGAP2 TUBB3
Entrez ID		26292	6091
HPRD ID		08406	03890
Ensembl ID		ENSG00000214114	ENSG00000169855
Uniprot IDs		Q99417	Q1RMC8 Q9Y6N7
PDB IDs		2YY0	2EO9 2V9Q 2V9R 2V9T 3WIH 4HLJ 5O5G 5O5I 5OPE 6A77 6A78 6A79
Enriched GO Terms of Interacting Partners?
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