FGF20 and PTX3

Data Source:
BioGRID (pull down)

		FGF20	PTX3
Description		fibroblast growth factor 20	pentraxin 3
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Extracellular Region Extracellular Space Extracellular Matrix Specific Granule Lumen Tertiary Granule Lumen
	Molecular Function	Signaling Receptor Binding Fibroblast Growth Factor Receptor Binding Growth Factor Activity Heparan Sulfate Proteoglycan Binding Receptor-receptor Interaction	Complement Component C1q Complex Binding (1->3)-beta-D-glucan Binding Protein Binding Identical Protein Binding Virion Binding
	Biological Process	MAPK Cascade Positive Regulation Of Protein Phosphorylation Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Population Proliferation Fibroblast Growth Factor Receptor Signaling Pathway Animal Organ Morphogenesis Positive Regulation Of Gene Expression Regulation Of Dopamine Secretion Cell Differentiation Regulation Of Cell Migration Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Protein Kinase B Signaling Regulation Of Cardiac Muscle Cell Proliferation Inner Ear Receptor Cell Differentiation Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Dopaminergic Neuron Differentiation	Ovarian Cumulus Expansion Response To Yeast Inflammatory Response Opsonization Extracellular Matrix Organization Neutrophil Degranulation Negative Regulation By Host Of Viral Process Negative Regulation By Host Of Viral Exo-alpha-sialidase Activity Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of Phagocytosis Negative Regulation Of Exo-alpha-sialidase Activity Negative Regulation Of Glycoprotein Metabolic Process
Pathways		PI3K Cascade PIP3 activates AKT signaling Signaling by activated point mutants of FGFR1 Signaling by activated point mutants of FGFR3 FGFR4 ligand binding and activation FGFR3b ligand binding and activation FGFR3c ligand binding and activation FGFR1c ligand binding and activation FGFR2c ligand binding and activation FGFR3 mutant receptor activation Activated point mutants of FGFR2 Constitutive Signaling by Aberrant PI3K in Cancer Phospholipase C-mediated cascade: FGFR1 Phospholipase C-mediated cascade; FGFR2 Phospholipase C-mediated cascade; FGFR3 Phospholipase C-mediated cascade; FGFR4 Downstream signaling of activated FGFR1 SHC-mediated cascade:FGFR1 PI-3K cascade:FGFR1 FRS-mediated FGFR1 signaling PI-3K cascade:FGFR2 SHC-mediated cascade:FGFR2 FRS-mediated FGFR2 signaling SHC-mediated cascade:FGFR3 FRS-mediated FGFR3 signaling PI-3K cascade:FGFR3 FRS-mediated FGFR4 signaling SHC-mediated cascade:FGFR4 PI-3K cascade:FGFR4 Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling Signaling by FGFR2 in disease Signaling by FGFR1 in disease RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signaling by FGFR3 point mutants in cancer	Neutrophil degranulation
Drugs
Diseases
GWAS		Allergic rhinitis in asthma ( 25085501) Attention function in attention deficit hyperactive disorder ( 26174813) General risk tolerance (MTAG) ( 30643258) Parkinson's disease ( 25064009) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Body mass index ( 26426971)
Interacting Genes		1 interacting genes: PTX3	15 interacting genes: C1QA C1QB C1QC CFH FGF1 FGF16 FGF17 FGF18 FGF2 FGF20 FGF22 FGF5 FGF7 FGF8 MTNR1A
Entrez ID		26281	5806
HPRD ID		05709	03928
Ensembl ID		ENSG00000078579	ENSG00000163661
Uniprot IDs		Q9NP95	P26022
PDB IDs		3F1R
Enriched GO Terms of Interacting Partners?
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