SACS and POLR1H

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SACS	POLR1H
Description		sacsin molecular chaperone	RNA polymerase I subunit H
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Axon Dendrite Cell Body Fiber	Nucleoplasm RNA Polymerase I Complex
	Molecular Function	Hsp70 Protein Binding Chaperone Binding Proteasome Binding	Nucleic Acid Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding
	Biological Process	Protein Folding Negative Regulation Of Inclusion Body Assembly	Nucleobase-containing Compound Metabolic Process Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription MRNA Cleavage Positive Regulation Of Gene Expression, Epigenetic
Pathways			NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Hypothyroidism ( 22493691) Metabolite levels ( 23823483) Protein quantitative trait loci ( 18464913) Type 2 diabetes ( 23300278)
Interacting Genes		6 interacting genes: ACTN4 ADRB2 PICK1 POLR1H TSC22D4 UBE3A	18 interacting genes: APOA1 ATXN2 CIC DUSP1 FHL3 GFI1B GPR20 HAX1 IL15 IVNS1ABP MAPK8IP2 NONO SACS SERPINA3 TNS2 TRIML2 UBE2I ZNF593
Entrez ID		26278	30834
HPRD ID		05135	09601
Ensembl ID		ENSG00000151835	ENSG00000066379
Uniprot IDs		Q9NZJ4	Q2L6J2 Q9P1U0
PDB IDs		1IUR 3O10 5V44 5V45 5V46 5VSX 5VSZ
Enriched GO Terms of Interacting Partners?
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