FBXO6 and RIOK1

Data Source:
BioGRID (unspecified method)

		FBXO6	RIOK1
Description		F-box protein 6	RIO kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Endoplasmic Reticulum Quality Control Compartment	Nucleoplasm Cytosol Preribosome, Small Subunit Precursor Methyltransferase Complex
	Molecular Function	Protein Binding Carbohydrate Binding Ubiquitin Protein Ligase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Hydrolase Activity Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	DNA Damage Checkpoint Protein Polyubiquitination DNA Repair Proteolysis Glycoprotein Catabolic Process Response To Unfolded Protein Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification	Protein Phosphorylation Maturation Of SSU-rRNA Ribosomal Small Subunit Biogenesis Positive Regulation Of RRNA Processing
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs			Fostamatinib
Diseases
GWAS		Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701)	Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		3 interacting genes: ORC4 RIOK1 SKP1	7 interacting genes: APP CSNK2A1 FBXO6 KDM1A SETD7 WDR77 YWHAB
Entrez ID		26270	83732
HPRD ID		07291	17978
Ensembl ID		ENSG00000116663	ENSG00000124784
Uniprot IDs		Q9NRD1	Q9BRS2
PDB IDs			4OTP 6G5I 6V0N
Enriched GO Terms of Interacting Partners?
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