PHGDH and SUMO4

Data Source:
HPRD (in vivo)

		PHGDH	SUMO4
Description		phosphoglycerate dehydrogenase	small ubiquitin like modifier 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Extracellular Exosome	Nucleus SUMO Ligase Complex
	Molecular Function	Phosphoglycerate Dehydrogenase Activity Electron Transfer Activity L-malate Dehydrogenase Activity NAD Binding	Molecular_function Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	Glutamine Metabolic Process Glycine Metabolic Process L-serine Biosynthetic Process Threonine Metabolic Process Brain Development Gamma-aminobutyric Acid Metabolic Process Regulation Of Gene Expression Taurine Metabolic Process Spinal Cord Development Glial Cell Development Neural Tube Development Electron Transport Chain Neuron Projection Development G1 To G0 Transition	Protein Sumoylation Cellular Response To Oxidative Stress Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of DNA Binding Negative Regulation Of DNA Binding Negative Regulation Of Transcription, DNA-templated Regulation Of Protein Localization To Nucleus
Pathways		Serine biosynthesis
Drugs		NADH
Diseases
GWAS		Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Amino acid levels ( 26068415) Blood metabolite levels ( 24816252) Glycine levels ( 31070104 30837465) Height ( 25282103) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) Macular telangiectasia type 2 ( 28250457) Mean corpuscular hemoglobin ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic traits ( 21886157) Metabolite levels ( 23378610) Multiple sclerosis ( 31604244 24076602) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Red blood cell count ( 32888494 27863252) Severe gingival inflammation ( 28459102) Total cholesterol levels ( 30275531)	Dupuytren's disease ( 28886342)
Interacting Genes		8 interacting genes: APP CHMP2B LINC01554 MAPK6 PIAS4 PJA1 SUMO4 TTN	75 interacting genes: ACADM ACO2 ACTG1 ALDOA ARHGDIA ATP5F1B CALR CAT CCT2 CCT5 CCT6A CCT7 CLIC1 DNAJA1 DNAJB11 EIF3I ENO1 ENO2 FOS G6PD GAPDH GMPS GSTP1 HNRNPD HNRNPF HNRNPH1 HNRNPL HSPA1B HSPA5 HSPA8 HSPA9 HSPD1 IDH1 IDH3A IMPDH2 JUN LDHB LMNA LMNB1 MRPS22 NFKBIA NR3C1 PA2G4 PAFAH1B3 PDIA3 PDIA6 PGK1 PHB PHGDH PITHD1 PPA1 PRDX2 PRDX3 PRDX4 PRDX6 PRPS1 PSMC2 RACK1 RPSA SF3B4 SPINT2 STAT1 STAT3 STIP1 STOML2 STRAP TFAP2A TOP2A TPM3 TUBA1C TXNL1 UBE2V1 VCP VDAC1 ZPR1
Entrez ID		26227	387082
HPRD ID		06047	10584
Ensembl ID		ENSG00000092621	ENSG00000177688
Uniprot IDs		O43175	Q6EEV6
PDB IDs		2G76 5N53 5N6C 5NZO 5NZP 5NZQ 5OFM 5OFV 5OFW 6CWA 6PLF 6PLG 6RIH 6RJ2 6RJ3 6RJ5 6RJ6 7CVP
Enriched GO Terms of Interacting Partners?
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