FBXW2 and EXOSC2

Data Source:
BioGRID (affinity chromatography technology)

		FBXW2	EXOSC2
Description		F-box and WD repeat domain containing 2	exosome component 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Protein Polyubiquitination Cellular Protein Modification Process Proteolysis Post-translational Protein Modification	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Association of TriC/CCT with target proteins during biosynthesis Neddylation Antigen processing: Ubiquitination & Proteasome degradation	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		10 interacting genes: BTRC CDC34 CLVS2 CTNNB1 CUL1 MSX2 MYB SKP1 TRIM54 UBE2D2	18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408
Entrez ID		26190	23404
HPRD ID		09950	03758
Ensembl ID		ENSG00000119402	ENSG00000130713
Uniprot IDs		B4DT60 Q9UKT8	B3KQW2 Q13868
PDB IDs			2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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