NPHP4 and FBXO44

Data Source:
BioGRID (two hybrid)

		NPHP4	FBXO44
Description		nephrocystin 4	F-box protein 44
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Ciliary Transition Zone Ciliary Basal Body Intracellular Membrane-bounded Organelle Ribbon Synapse Ciliary Base Non-motile Cilium Photoreceptor Distal Connecting Cilium	Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Structural Molecule Activity Protein Binding	Protein Binding Ubiquitin Protein Ligase Activity
	Biological Process	Signal Transduction Visual Behavior Actin Cytoskeleton Organization Flagellated Sperm Motility Hippo Signaling Photoreceptor Cell Outer Segment Organization Photoreceptor Cell Maintenance Retina Development In Camera-type Eye Negative Regulation Of Canonical Wnt Signaling Pathway Ciliary Basal Body-plasma Membrane Docking Cell-cell Adhesion Positive Regulation Of Bicellular Tight Junction Assembly Protein Localization To Ciliary Transition Zone	Protein Polyubiquitination Glycoprotein Catabolic Process Proteasomal Protein Catabolic Process Ubiquitin-dependent ERAD Pathway SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification
Pathways		Signaling by Hippo Anchoring of the basal body to the plasma membrane	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Senior-Loken syndrome Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Dimensional psychopathology (Positive) ( 29496196) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) QT interval ( 19305408) Response to taxane treatment (placlitaxel) ( 23006423)	Arterial stiffness (brachial-femoral pulse wave velocity) ( 32790701) Neurological blood protein biomarker levels ( 31320639)
Interacting Genes		2 interacting genes: NPHP1 RPGRIP1	12 interacting genes: BLOC1S1 BORCS6 BRCA1 C11orf45 HSF2BP ISY1-RAB43 MEOX2 PRDM5 SERTAD3 SKP1 SPG21 UBC
Entrez ID		261734	93611
HPRD ID		06238	16445
Ensembl ID		ENSG00000131697	ENSG00000132879
Uniprot IDs		B3KW36 O75161	A0A024R4F9 A0A024R4J6 B7Z1P2 Q9H4M3
PDB IDs			3WSO 5B4N
Enriched GO Terms of Interacting Partners?
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