TES and SPTAN1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo)

		TES	SPTAN1
Description		testin LIM domain protein	spectrin alpha, non-erythrocytic 1
Image
GO Annotations	Cellular Component	Nucleus Cytosol Plasma Membrane Focal Adhesion Cell Junction Protein-containing Complex	Extracellular Region Cytosol Spectrin Microtubule Cytoskeleton Membrane Specific Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	RNA Binding Protein Binding Zinc Ion Binding Cadherin Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding
	Biological Process	Negative Regulation Of Cell Population Proliferation	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Neutrophil Degranulation Actin Filament Capping
Pathways			Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport
Drugs
Diseases			Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Chronotype ( 30696823) Glaucoma ( 31959993 30054594) Intraocular pressure ( 31959993 30054594 29235454) Metabolite levels ( 23823483)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		13 interacting genes: ACTL7A ACTN1 ALKBH4 ARAP1 ENAH EVL GRIPAP1 SOCS3 SPOCK2 SPTAN1 TLN1 VASP ZYX	56 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D KALRN KARS1 MAPK6 NEFL PDE4D PIN4 PLEC PLEKHA5 PRKCB PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN2 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 ZNF333
Entrez ID		26136	6709
HPRD ID		05833	01684
Ensembl ID		ENSG00000135269	ENSG00000197694
Uniprot IDs		A4D0U5 Q9UGI8	A0A384P5S9 Q13813
PDB IDs		2IYB 2XQN	2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH
Enriched GO Terms of Interacting Partners?
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