SPTAN1 and PIN4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SPTAN1	PIN4
Description		spectrin alpha, non-erythrocytic 1	peptidylprolyl cis/trans isomerase, NIMA-interacting 4
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GO Annotations	Cellular Component	Extracellular Region Cytosol Spectrin Microtubule Cytoskeleton Membrane Specific Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen	Nucleoplasm Chromosome Nucleolus Mitochondrial Matrix Spindle
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding	DNA Binding RNA Binding Peptidyl-prolyl Cis-trans Isomerase Activity Protein Binding
	Biological Process	MAPK Cascade Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Neutrophil Degranulation Actin Filament Capping	Protein Peptidyl-prolyl Isomerization RRNA Processing
Pathways		Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport
Drugs
Diseases		Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Axial length ( 24144296) Body mass index ( 26426971)	Rosacea symptom severity ( 29771307)
Interacting Genes		56 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D KALRN KARS1 MAPK6 NEFL PDE4D PIN4 PLEC PLEKHA5 PRKCB PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN2 SPTBN4 SRC STAT1 SUMO2 SYN1 TAF1 TANC1 TES TSSC4 ZNF333	18 interacting genes: ASCC2 CEP72 CSNK2A1 CSNK2A2 DNM1 EGFR ERBB2 ERBB3 ERBB4 EZH2 FAM9B FATE1 FBL FRMD1 MAGEA11 PNMA1 SPTAN1 ZBTB9
Entrez ID		6709	5303
HPRD ID		01684	02219
Ensembl ID		ENSG00000197694	ENSG00000102309
Uniprot IDs		A0A384P5S9 Q13813	Q9Y237
PDB IDs		2FOT 3F31 3FB2 5FW9 5FWB 5FWC 6ZEH	1EQ3 1FJD 3UI4 3UI5 3UI6
Enriched GO Terms of Interacting Partners?
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