AAR2 and SAMHD1

Data Source:
BioGRID (genetic interference)

		AAR2	SAMHD1
Description		AAR2 splicing factor	SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1
Image		No pdb structure
GO Annotations	Cellular Component	Spliceosomal Complex U5 SnRNP	Nucleus Nucleoplasm Plasma Membrane Site Of Double-strand Break Tetraspanin-enriched Microdomain
	Molecular Function		Nucleic Acid Binding Single-stranded DNA Binding RNA Binding Ribonuclease Activity Protein Binding GTP Binding Zinc Ion Binding DGTPase Activity Triphosphoric Monoester Hydrolase Activity DGTP Binding Identical Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly	Double-strand Break Repair Via Homologous Recombination DGTP Catabolic Process Immune Response Cellular Response To DNA Damage Stimulus Deoxyribonucleotide Catabolic Process Viral Process Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Innate Immune Response DATP Catabolic Process Protein Homotetramerization Defense Response To Virus Type I Interferon Signaling Pathway Negative Regulation Of Type I Interferon-mediated Signaling Pathway RNA Phosphodiester Bond Hydrolysis DNA Strand Resection Involved In Replication Fork Processing
Pathways			Nucleobase catabolism Interferon alpha/beta signaling
Drugs
Diseases			Aicardi-Goutieres Syndrome (AGS)
GWAS		Refractive error ( 32231278)	Height ( 28552196)
Interacting Genes		2 interacting genes: EAPP GJA5	11 interacting genes: ACTB APP ARAP3 DCAF1 DYSF FAM13B FBXO25 FBXO7 SUMO2 TIRAP TRIM21
Entrez ID		25980	25939
HPRD ID		12767	08418
Ensembl ID		ENSG00000131043	ENSG00000101347
Uniprot IDs		Q9Y312	Q59H15 Q9Y3Z3
PDB IDs			2E8O 3U1N 4BZB 4BZC 4CC9 4MZ7 4Q7H 4QFX 4QFY 4QFZ 4QG0 4QG1 4QG2 4QG4 4RXO 4RXP 4RXQ 4RXR 4RXS 4TNP 4TNQ 4TNR 4TNX 4TNY 4TNZ 4TO0 4TO1 4TO2 4TO3 4TO4 4TO5 4TO6 4ZWE 4ZWG 5AO0 5AO1 5AO2 5AO3 5AO4 6CM2 6DW3 6DW4 6DW5 6DW7 6DWD 6DWJ 6DWK 6TX0 6TXA 6TXC 6TXE 6TXF 6U6X 6U6Y 6U6Z 6XU1 6YOM
Enriched GO Terms of Interacting Partners?
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