NECAP1 and AP1B1

Data Source:
BioGRID (two hybrid)

		NECAP1	AP1B1
Description		NECAP endocytosis associated 1	adaptor related protein complex 1 subunit beta 1
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GO Annotations	Cellular Component	Cytosol Clathrin-coated Pit Clathrin Vesicle Coat	Golgi Membrane Lysosomal Membrane Golgi Apparatus Cytosol Clathrin Adaptor Complex Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	Protein Binding Protein Kinase Binding Clathrin Binding
	Biological Process	Endocytosis Protein Transport Vesicle-mediated Transport Membrane Organization	Kidney Development Intracellular Protein Transport Determination Of Left/right Symmetry Heart Development Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus
Pathways		Golgi Associated Vesicle Biogenesis Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS			Carotid atherosclerosis in HIV infection ( 20009918) Heel bone mineral density ( 30598549 28869591) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494 27863252) Pancreatic cancer ( 25086665) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		9 interacting genes: AMPH AP1B1 APP DAB2 DAPK1 DNAJC5 HIP1 REL SNAP91	43 interacting genes: AGR3 AP1G1 AP1G2 AP1M2 ARF1 ARF5 ARF6 ARRB2 ATF7IP ATM ATR BARD1 BUB1 BUB1B CLTC CREBBP CRYBB1 FARS2 FMNL2 FNDC11 GPANK1 GTF2I KIF13A LDLRAP1 MLH1 MSGN1 MTNR1B MYG1 NECAP1 NTRK2 NUP54 PIP5K1C POM121 PRKDC PSORS1C2 RNF39 SHBG SLC2A8 SMAD2 TBC1D22B TSGA10IP U2AF1 U2AF1L5
Entrez ID		25977	162
HPRD ID		14819	02541
Ensembl ID		ENSG00000089818	ENSG00000100280
Uniprot IDs		Q8NC96	Q10567
PDB IDs		6RH5 6RH6	4HMY 4P6Z 6CM9 6CRI 6D83 6D84 6DFF
Enriched GO Terms of Interacting Partners?
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