TIPARP and XRN2

Data Source:
HPRD (two hybrid)

		TIPARP	XRN2
Description		TCDD inducible poly(ADP-ribose) polymerase	5'-3' exoribonuclease 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Nucleolus Membrane Aggresome
	Molecular Function	Cis-regulatory Region Sequence-specific DNA Binding NAD+ ADP-ribosyltransferase Activity Metal Ion Binding Protein ADP-ribosylase Activity	3'-5'-exoribonuclease Activity Transcription Termination Site Sequence-specific DNA Binding RNA Binding Nuclease Activity 5'-3' Exoribonuclease Activity Protein Binding 5'-3' Exonuclease Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Vasculogenesis Kidney Development Protein ADP-ribosylation Androgen Metabolic Process Estrogen Metabolic Process Female Gonad Development Post-embryonic Development Negative Regulation Of Gene Expression Hemopoiesis Positive Regulation Of Protein Catabolic Process Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Roof Of Mouth Development Face Morphogenesis Protein Auto-ADP-ribosylation Cellular Response To Organic Cyclic Compound Protein Mono-ADP-ribosylation Response To 2,3,7,8-tetrachlorodibenzodioxine	DNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process DNA-templated Transcription, Termination RRNA Processing RNA Processing MRNA Processing RNA Catabolic Process Spermatogenesis RNA Metabolic Process Hippocampus Development Neuron Differentiation Retina Development In Camera-type Eye RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways			Association of TriC/CCT with target proteins during biosynthesis Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Adult body size ( 32376654) Central corneal thickness ( 29760442) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Chronotype ( 30696823) Epithelial ovarian cancer ( 25581431) Malaria ( 31844061) Nose size ( 27182965) Ovarian cancer ( 20852632) Testicular germ cell tumor ( 28604732) Youthful appearance (self-reported) ( 32339537)	Autism spectrum disorder ( 30804558) Lupus nephritis in systemic lupus erythematosus ( 24925725) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Red cell distribution width ( 32888494)
Interacting Genes		2 interacting genes: ATM XRN2	28 interacting genes: ALDH1B1 ATRN COMT CRY2 CSNK2A1 CTSC DXO DYNLT1 EEF1A1 EIF3L EIF5A EIF6 ERG EXOSC10 EXOSC8 LCN2 LSM3 MOCS3 MRPL4 MRPS10 PLEKHF2 PRAME PSMA3 TARDBP TIPARP TOLLIP TTC23 UPF2
Entrez ID		25976	22803
HPRD ID		18192	10309
Ensembl ID		ENSG00000163659	ENSG00000088930
Uniprot IDs		Q05BQ2 Q7Z3E1	B4DZC3 Q9H0D6
PDB IDs
Enriched GO Terms of Interacting Partners?
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