SGMS1 and STK4

Data Source:
BioGRID (enzymatic study)

		SGMS1	STK4
Description		sphingomyelin synthase 1	serine/threonine kinase 4
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Trans Cisterna Golgi Membrane Nucleus Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Membrane Integral Component Of Golgi Membrane Integral Component Of Endoplasmic Reticulum Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body Protein-containing Complex
	Molecular Function	Ceramide Phosphoethanolamine Synthase Activity Kinase Activity Sphingomyelin Synthase Activity Ceramide Cholinephosphotransferase Activity	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Transcription Factor Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Sphingomyelin Biosynthetic Process Apoptotic Process Inflammatory Response Positive Regulation Of Gene Expression Phosphorylation Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Morphogenesis Branching Involved In Blood Vessel Morphogenesis Neural Tube Formation Positive Regulation Of Protein Phosphorylation Endocardium Development Protein Phosphorylation Apoptotic Process Central Nervous System Development Negative Regulation Of Cell Population Proliferation Peptidyl-serine Phosphorylation Keratinocyte Differentiation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Organ Growth Protein Autophosphorylation Protein Stabilization Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process
Pathways		Sphingolipid de novo biosynthesis	Signaling by Hippo
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cobalt levels ( 26025379) LDL cholesterol levels ( 32203549) Metabolite levels ( 31628463) Neurological blood protein biomarker levels ( 31320639) Pulse pressure ( 30578418) Response to amphetamines ( 22952603) Triglyceride levels ( 32203549)	Bipolar disorder ( 31043756) Mean platelet volume ( 32888494) Platelet count ( 32888494)
Interacting Genes		2 interacting genes: ATXN1 STK4	23 interacting genes: AKT1 CASP3 CNKSR1 CSN1S1 DAXX DDIT4L H2BC21 IL2RG KEAP1 LATS1 MARK2 MBP NEDD4 PICK1 RASSF1 RASSF5 RNF31 SAV1 SGMS1 SIRT1 STK3 THAP12 TP53
Entrez ID		259230	6789
HPRD ID		18203	05395
Ensembl ID		ENSG00000198964	ENSG00000101109
Uniprot IDs		Q86VZ5	Q13043
PDB IDs			2JO8 3COM 4NR2 4OH8 5TWG 5TWH 6YAT
Enriched GO Terms of Interacting Partners?
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