NCR3 and CD247

Data Source:
HPRD (in vitro, in vivo)

		NCR3	CD247
Description		natural cytotoxicity triggering receptor 3	CD247 molecule
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex
	Molecular Function	Protein Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Immune Response-activating Cell Surface Receptor Signaling Pathway Inflammatory Response Immune Response Cell Recognition Natural Killer Cell Activation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response	Adaptive Immune Response Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Defense Response To Virus By Virus Regulation Of Immune Response T Cell Receptor Signaling Pathway Positive Regulation Of Protein Localization To Cell Surface
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs			Muromonab
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 29875488 28240269) Hypertension ( 30226566) Inflammatory bowel disease ( 28067908) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213) Malaria ( 31844061) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Takayasu arteritis ( 25604533) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Weight ( 19079260)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 31361310) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (childhood onset) ( 30929738) Asthma (moderate or severe) ( 30552067) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Celiac disease ( 20190752) Celiac disease or Rheumatoid arthritis ( 21383967) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (glucocorticoids) ( 31015401) Medication use (thyroid preparations) ( 31015401) Pre-treatment viral load in HIV-1 infection ( 31219150) Rheumatoid arthritis ( 20453842) Systemic sclerosis ( 21750679 31672989 20383147 29293537 21779181)
Interacting Genes		5 interacting genes: BAG6 CD247 CD59 FAM209A FCER1G	38 interacting genes: CD2 CD244 CD28 CD3D CD48 CD5 CSK DOCK2 FCGR3A FYN GAB2 GRB2 JAK3 LCK LY6E NCR1 NCR3 PCGF2 PI4K2B PTPN22 PTPN3 PTPN6 PTPRC SH2B3 SHC1 SLA SLA2 STAT5A STAT5B TFRC TIRAP TRA TRAT1 TRB UNC119 VTN ZAP70 ZNF281
Entrez ID		259197	919
HPRD ID		11384	01729
Ensembl ID		ENSG00000204475	ENSG00000198821
Uniprot IDs		O14931 Q05D23	P20963
PDB IDs		3NOI 3PV6 6YJP	1TCE 1YGR 2HAC 2OQ1 3IK5 3IOZ 4XZ1 6JXR
Enriched GO Terms of Interacting Partners?
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