ANAPC15 and CEP19

Data Source:
BioGRID (two hybrid)

		ANAPC15	CEP19
Description		anaphase promoting complex subunit 15	centrosomal protein 19
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Anaphase-promoting Complex Cytosol	Spindle Pole Cytoplasm Centrosome Centriole Cilium Ciliary Basal Body
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Cell Cycle Anaphase-promoting Complex-dependent Catabolic Process Cell Division Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Regulation Of Mitotic Cell Cycle Phase Transition	Microtubule Anchoring At Centrosome Cilium Assembly Vesicle Targeting, Trans-Golgi To Periciliary Membrane Compartment
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects
Drugs
Diseases
GWAS			Allergic disease (asthma, hay fever or eczema) ( 29083406) Asthma ( 31959851 30929738)
Interacting Genes		3 interacting genes: ABL1 CDKN2A CEP19	50 interacting genes: AK4 ANAPC15 C4orf19 CALCOCO1 CCDC102B CCDC106 CCDC74A CDR1 CEP350 CEP43 CREB3L2 CREB3L3 EVI5 FOXR1 GMEB2 GNL3 HSPB2 HSPB2-C11orf52 KIAA1958 KXD1 LYSMD2 NOTO PAPSS2 PEX13 PIBF1 PICK1 PIK3R3 PLEKHO1 PRAP1 PRKAR1B PTPN23 RABL2A RABL2B REL ROBO4 SENP3 SYNE4 TNNI1 TRAIP TSPYL2 TVP23B TXLNB VCP VPS52 ZBTB10 ZBTB14 ZFP1 ZNF420 ZNF438 ZNF81
Entrez ID		25906	84984
HPRD ID		13172	17488
Ensembl ID		ENSG00000110200	ENSG00000174007
Uniprot IDs		A0A024R5G0 G5EA39 P60006	Q96LK0
PDB IDs		4UI9 5A31 5G04 5G05 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5
Enriched GO Terms of Interacting Partners?
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