SPEF1 and ZBED1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SPEF1	ZBED1
Description		sperm flagellar 1	zinc finger BED-type containing 1
Image
GO Annotations	Cellular Component	Cytoplasm Microtubule Microvillus Axoneme Basolateral Plasma Membrane Apical Plasma Membrane Lamellipodium Filopodium Ciliary Tip 9+2 Motile Cilium Axonemal Central Apparatus	Chromatin Nucleus Nucleoplasm Centrosome PML Body Nuclear Membrane
	Molecular Function	Molecular_function Actin Binding Protein Binding Microtubule Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding SUMO Transferase Activity Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding Protein Dimerization Activity SUMO Ligase Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Microtubule Bundle Formation Cilium Movement Negative Regulation Of Microtubule Depolymerization Cell Migration Lamellipodium Assembly Filopodium Assembly Regulation Of Cytoskeleton Organization Negative Regulation Of Cell Death Axonemal Central Apparatus Assembly Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Viral Process Negative Regulation By Host Of Viral Genome Replication Positive Regulation Of Transcription By RNA Polymerase II Protein Autosumoylation
Pathways			SUMOylation of chromatin organization proteins
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal volume ( 29860282) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)
Interacting Genes		5 interacting genes: CYSRT1 KRT40 KRTAP13-2 PLEKHF2 ZBED1	55 interacting genes: AMOTL2 ATRX C1orf109 CCDC13 CDC37 CTNNAL1 DGCR6 EFHC1 FABP4 FAM124B FANCG FNDC11 GGACT GORASP2 GPN1 GPSM1 KDM1A KIFC3 KLHL40 LCN2 LNX1 LRRC20 MAD2L2 MAGEB2 MKKS MLH1 MPST MYO15B NCDN NIF3L1 NIP7 NTAQ1 NUDT18 PAX6 PIAS2 PICK1 POLE2 POLR1C PRKAA1 PRKAR1A PSAP RENBP RIN1 SORBS3 SPEF1 SSX2 SUMO2 TRAPPC2 TRAPPC2B TRIML2 TTC23 TTR UBE2I UCHL5 USP2
Entrez ID		25876	9189
HPRD ID		09839	02170
Ensembl ID		ENSG00000101222	ENSG00000214717
Uniprot IDs		Q9Y4P9	A0A024RBU4 O96006
PDB IDs		2EE7	2CT5
Enriched GO Terms of Interacting Partners?
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