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UBASH3A and TP63
Data Source:
BioGRID
(two hybrid)
UBASH3A
TP63
Description
ubiquitin associated and SH3 domain containing A
tumor protein p63
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Golgi Apparatus
Cytosol
Extracellular Exosome
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrion
Rough Endoplasmic Reticulum
Dendrite
Protein-containing Complex
Molecular Function
Protein Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
P53 Binding
DNA Binding
Chromatin Binding
Damaged DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Identical Protein Binding
Metal Ion Binding
WW Domain Binding
MDM2/MDM4 Family Protein Binding
Biological Process
Regulation Of Cytokine Production
Negative Regulation Of T Cell Receptor Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Skeletal System Development
Establishment Of Planar Polarity
Epithelial Cell Development
Chromatin Remodeling
Regulation Of Transcription By RNA Polymerase II
Apoptotic Process
Notch Signaling Pathway
Spermatogenesis
Ectoderm And Mesoderm Interaction
Cell Aging
Cell Population Proliferation
Proximal/distal Pattern Formation
Multicellular Organism Aging
Epidermal Cell Division
Regulation Of Epidermal Cell Division
Positive Regulation Of Keratinocyte Proliferation
Keratinocyte Differentiation
Polarized Epithelial Cell Differentiation
Hair Follicle Morphogenesis
Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway
Embryonic Forelimb Morphogenesis
Embryonic Hindlimb Morphogenesis
Post-anal Tail Morphogenesis
Odontogenesis Of Dentin-containing Tooth
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Regulation Of Apoptotic Process
Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Skin Morphogenesis
Negative Regulation Of Keratinocyte Differentiation
Positive Regulation Of Osteoblast Differentiation
Positive Regulation Of Notch Signaling Pathway
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
Sympathetic Nervous System Development
Female Genitalia Morphogenesis
Protein Tetramerization
Neuron Apoptotic Process
Cloacal Septation
Prostatic Bud Formation
Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development
Establishment Of Skin Barrier
Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Regulation Of Signal Transduction By P53 Class Mediator
Positive Regulation Of Somatic Stem Cell Population Maintenance
Cranial Skeletal System Development
Positive Regulation Of Fibroblast Apoptotic Process
Negative Regulation Of Mesoderm Development
Positive Regulation Of Apoptotic Signaling Pathway
Pathways
Activation of PUMA and translocation to mitochondria
TP53 Regulates Metabolic Genes
TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
TP53 Regulates Transcription of Caspase Activators and Caspases
TP53 Regulates Transcription of Death Receptors and Ligands
Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
Limb-mammary syndrome
ADULT syndrome
Split-hand/foot malformation (SHFM)
Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
Ectrodactyly-ectodermal dysplasia cleft-palate syndrome (EEC syndrome)
Ankyloblepharon-ctodermal defects-cleft lip/palate (AEC) syndrome and Rapp-Hodgkin syndrome
GWAS
Asthma (
32296059
)
Autoimmune traits (pleiotropy) (
30572963
)
Celiac disease (
22057235
30572963
)
Celiac disease and Rheumatoid arthritis (
26546613
)
Celiac disease or Rheumatoid arthritis (
21383967
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Diverticular disease (
30177863
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Lymphocyte counts (
32888494
)
Medication use (thyroid preparations) (
31015401
)
Monocyte count (
32888494
)
Primary sclerosing cholangitis (
27992413
)
Rheumatoid arthritis (
30423114
24390342
20453842
)
Rheumatoid arthritis (ACPA-positive) (
24532676
)
Type 1 diabetes (
21829393
25751624
19430480
30572963
18840781
)
Vitiligo (
20410501
27723757
)
Acute lymphoblastic leukemia (childhood) (
22076464
)
Bladder cancer (
24163127
20972438
)
Brain imaging (
20100581
)
Chlamydia trachomatis PorB antibody levels (
33204752
)
Circulating leptin levels in high cardiovascular risk (
31766143
)
Cleft lip with or without cleft palate (
28054174
)
Cutaneous squamous cell carcinoma (
32041948
)
EGFR mutation-positive lung adenocarcinoma (
27501781
)
Lung adenocarcinoma (
28604730
22797724
20871597
)
Lung cancer (
28604730
21725308
23143601
24880342
)
Lung cancer in never smokers (
31009812
)
Metabolite levels (
23823483
)
Non-small cell lung cancer (
31326317
)
Orofacial clefts (
28054174
)
Pancreatic cancer (
29422604
26098869
)
Postoperative stroke after cardiac surgery (
30678657
)
Psoriasis (
25903422
)
Psoriasis vulgaris (
26626624
)
Squamous cell carcinoma (
26829030
)
Systemic lupus erythematosus (
28714469
)
Urinary bladder cancer (
20348956
18794855
)
Interacting Genes
89 interacting genes:
ARRDC1
ARRDC3
BCAR3
C9orf24
CBLB
CBS
CCDC33
CD3E
COPS9
DAZAP2
DDIT4L
DISC1
DLGAP4
DNM2
DTX3
FADS6
FAM83A
FGFR1OP2
GFAP
GOLGA6L9
HSP90AA1
HSP90B1
HSPD1
IKBKG
ISY1-RAB43
KCNE1
KCTD1
KIAA0408
KPRP
KRT14
KRT31
KRT32
KRT35
KRT39
KRT40
LCN2
LNX1
LZTS1
LZTS2
MAP3K7
MKRN1
N4BP3
NSMF
PLEKHB2
PMEPA1
PNMA5
PRDM6
PRKN
PSMC1
PSMC4
REL
RNF216
RNF41
SF3B4
SH3RF1
SHISA6
SLA2
SNRNP48
SOS1
SPRY1
SPRY2
STX11
TAX1BP1
TEKT1
TEKT4
TIMM44
TMCO2
TMEM239
TP53BP2
TP63
TRIM27
TRIM37
TRIM5
TRIM50
TRIM8
TUBB8
UBB
UBC
UBE2L3
VCP
VPS37B
WAS
WASL
WBP11
ZBTB42
ZC2HC1C
ZNF219
ZNF474
ZRANB1
41 interacting genes:
BAG6
BTRC
CCNC
CDC20
CDKN2A
COPS6
CSNK2A1
CSNK2A2
CSNK2B
DAXX
EMX1
EP300
GCGR
GRB2
HIPK2
HNRNPAB
HP
HPX
ITCH
ITIH4
KAT2B
MCRS1
MDM4
NIPSNAP3A
ORM1
PELI1
PELI2
PIN1
PINX1
PML
PPP1R13B
PPP2R5A
RACK1
RCHY1
SCAF4
SLC35A3
TP53
TP73
UBASH3A
UBE2I
WT1
Entrez ID
53347
8626
HPRD ID
06904
04469
Ensembl ID
ENSG00000160185
ENSG00000073282
Uniprot IDs
P57075
A0A0S2Z4N5
A0A0S2Z4N6
A0A141PNN3
A0A141PNN4
B7Z8X6
C9D7D0
Q9H3D4
PDB IDs
2CRN
5WDI
1RG6
2NB1
2RMN
2Y9T
2Y9U
3QYM
3QYN
3US0
3US1
3US2
3ZY0
3ZY1
4A9Z
6FGN
6RU6
6RU7
6RU8
Enriched GO Terms of Interacting Partners
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