BAMBI and ACVRL1

Data Source:
BioGRID (pull down)

		BAMBI	ACVRL1
Description		BMP and activin membrane bound inhibitor	activin A receptor like type 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Membrane	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex BMP Receptor Complex
	Molecular Function	Frizzled Binding Type II Transforming Growth Factor Beta Receptor Binding Protein Binding	Protein Serine/threonine Kinase Activity Transmembrane Receptor Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type I Protein Binding ATP Binding Activin Receptor Activity, Type I Protein Kinase Binding SMAD Binding Metal Ion Binding Activin Binding Transforming Growth Factor Beta Binding BMP Receptor Activity
	Biological Process	Transforming Growth Factor Beta Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Shape Positive Regulation Of Epithelial To Mesenchymal Transition Cell Migration Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Binding Negative Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Canonical Wnt Signaling Pathway	Angiogenesis Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Maturation Blood Vessel Remodeling Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Endocardial Cushion Morphogenesis Regulation Of DNA Replication Regulation Of Transcription, DNA-templated Protein Phosphorylation Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Heart Development Blood Circulation Regulation Of Blood Pressure Negative Regulation Of Cell Population Proliferation Dorsal/ventral Pattern Formation Negative Regulation Of Endothelial Cell Migration Negative Regulation Of Gene Expression Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Positive Regulation Of Chondrocyte Differentiation Activin Receptor Signaling Pathway Wound Healing, Spreading Of Epidermal Cells Dorsal Aorta Morphogenesis Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Focal Adhesion Assembly Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Endothelial Tube Morphogenesis Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Cellular Response To Transforming Growth Factor Beta Stimulus Cellular Response To BMP Stimulus Endocardial Cushion To Mesenchymal Transition Negative Regulation Of DNA Biosynthetic Process
Pathways		Downregulation of TGF-beta receptor signaling	Signaling by BMP
Drugs			ATP
Diseases			Hereditary hemorrhagic telangiectasia (HHT)
GWAS		Cataracts (operation) ( 31816047) Fasting glucose change (long-term) ( 31263163) Intraocular pressure ( 29617998) Metabolite levels ( 23823483) Percentage gas trapping ( 26030696) Preeclampsia ( 23551011)	Hematocrit ( 29403010) Hemoglobin ( 29403010 32888494) Hemoglobin levels ( 32327693) Lymphocyte counts ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Monocyte count ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494 27863252) Urate levels ( 23263486) White blood cell count ( 32888494 27863252)
Interacting Genes		9 interacting genes: ACVR1 ACVR1B ACVRL1 BMPR1A BMPR1B NKG7 SELENOF SOX30 TGFBR1	13 interacting genes: ACVR2A BAMBI CSNK2B FKBP1A GDF2 SMAD1 SNX6 TGFB1 TGFB3 TGFBR1 TGFBR2 TGFBRAP1 XIAP
Entrez ID		25805	94
HPRD ID		05117	03181
Ensembl ID		ENSG00000095739	ENSG00000139567
Uniprot IDs		Q13145	A0A0S2Z310 P37023
PDB IDs			2LCR 3MY0 4FAO 6SF1 6SF2 6SF3
Enriched GO Terms of Interacting Partners?
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