LSM4 and SMU1

Data Source:
BioGRID (two hybrid)

		LSM4	SMU1
Description		LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated	SMU1 DNA replication regulator and spliceosomal factor
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol Membrane Protein-containing Complex U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Spliceosomal Tri-snRNP Complex Lsm2-8 Complex	Nucleus Cytoplasm Nuclear Speck U2-type Precatalytic Spliceosome Precatalytic Spliceosome
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding PH Domain Binding	Protein Binding
	Biological Process	Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome RNA Splicing P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA	Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Splicing, Via Spliceosome RNA Splicing Viral Process
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Chronotype ( 30696823) Estimated glomerular filtration rate ( 30604766) Gastroesophageal reflux disease ( 31527586) Intraocular pressure ( 29617998) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Red blood cell count ( 32888494 27863252) Reticulocyte count ( 32888494)	Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223)
Interacting Genes		21 interacting genes: CALCOCO2 COX5B EXOSC8 GAS7 HOMEZ IKZF1 L3MBTL3 LSM7 NMI PLEKHA5 PSTPIP1 RHOXF2 SLC22A2 SMIM14 SMN1 SMU1 SNRPE TOE1 TOP1 XRN1 ZBTB10	12 interacting genes: CD2BP2 CERT1 H2BC21 IK LSM4 LSM8 MRFAP1 MRFAP1L1 MSS51 RASSF10 TLX3 YBX1
Entrez ID		25804	55234
HPRD ID		06284	11588
Ensembl ID		ENSG00000130520	ENSG00000122692
Uniprot IDs		Q9Y4Z0 U3KQK1	A0MNN4 Q2TAY7
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	5O9Z 6AHD 6Q8F 6Q8I 6Q8J
Enriched GO Terms of Interacting Partners?
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