SUN2 and ALS2

Data Source:
BioGRID (affinity chromatography technology)

		SUN2	ALS2
Description		Sad1 and UNC84 domain containing 2	alsin Rho guanine nucleotide exchange factor ALS2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Condensed Nuclear Chromosome Nuclear Envelope Integral Component Of Nuclear Inner Membrane Endosome Membrane Nuclear Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex	Ruffle Nucleus Early Endosome Centrosome Cytosol Lamellipodium Dendrite Growth Cone Vesicle Protein-containing Complex
	Molecular Function	Protein Binding Lamin Binding Microtubule Binding Identical Protein Binding Protein-membrane Adaptor Activity Cytoskeleton-nuclear Membrane Anchor Activity	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine/threonine Kinase Activator Activity
	Biological Process	Nuclear Envelope Organization Mitotic Spindle Organization Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Meiotic Cell Cycle Centrosome Localization Nuclear Matrix Anchoring At Nuclear Membrane	Endosome Organization Lysosomal Transport Positive Regulation Of Rac Protein Signal Transduction Positive Regulation Of GTPase Activity Positive Regulation Of Protein Kinase Activity Neuron Projection Morphogenesis Regulation Of Endosome Size Protein Homooligomerization Positive Regulation Of Protein Serine/threonine Kinase Activity
Pathways		Meiotic synapsis	RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Juvenile primary lateral sclerosis
GWAS		Heel bone mineral density ( 28869591) Prostate cancer ( 31562322) Resting heart rate ( 27798624) Sleep duration ( 30846698)	Perceived intensity of neohesperidin dihydrochalcone ( 31005972) Perceived intensity of sweet substances ( 31005972)
Interacting Genes		4 interacting genes: HGS NRM RAB5B RPS20	1 interacting genes: YWHAB
Entrez ID		25777	57679
HPRD ID		15611	05893
Ensembl ID		ENSG00000100242	ENSG00000003393
Uniprot IDs		A0A024R1P7 B4E2A6 Q9UH99	A8K4R4 Q96Q42
PDB IDs		3UNP 4DXR 4DXS 4DXT 4FI9
Enriched GO Terms of Interacting Partners?
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