GABBR1 and NSF

Data Source:
HPRD (in vivo)

		GABBR1	NSF
Description		gamma-aminobutyric acid type B receptor subunit 1	N-ethylmaleimide sensitive factor, vesicle fusing ATPase
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite G Protein-coupled Receptor Heterodimeric Complex Presynaptic Membrane Postsynaptic Membrane Schaffer Collateral - CA1 Synapse GABA-ergic Synapse	Golgi Membrane Lysosomal Membrane Golgi Apparatus Golgi Stack Cytosol Plasma Membrane Postsynaptic Density Dendritic Shaft
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	SNARE Binding Protein Binding ATP Binding ATPase Activity Syntaxin-1 Binding Protein Kinase Binding PDZ Domain Binding Small GTPase Binding Ionotropic Glutamate Receptor Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Regulation Of Postsynaptic Membrane Potential Neuron-glial Cell Signaling	Positive Regulation Of Receptor Recycling Potassium Ion Transport Intracellular Protein Transport Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Vesicle-mediated Transport Regulation Of Exocytosis SNARE Complex Disassembly Golgi To Plasma Membrane Protein Transport Plasma Membrane Fusion Positive Regulation Of Protein Catabolic Process COPII Vesicle Coating Golgi Vesicle Docking
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	COPII-mediated vesicle transport Trafficking of GluR2-containing AMPA receptors COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Intra-Golgi traffic Retrograde transport at the Trans-Golgi-Network
Drugs		Baclofen Progabide Taurine gamma-Aminobutyric acid SGS-742 Tezampanel Arbaclofen Arbaclofen Placarbil	1-Ethyl-Pyrrolidine-2,5-Dione
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 28552196) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nasopharyngeal carcinoma ( 19664746) Nicotine dependence ( 28440896) Platelet count ( 26805783) Schizophrenia ( 27922604) Subcortical volume (MOSTest) ( 32665545) Ulna and radius bone mineral density ( 30172743) White blood cell count ( 27863252)	Alcohol use disorder (total score) ( 30336701) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Cortical surface area (global PC1) ( 32198502) General factor of neuroticism ( 30867560) Handedness (Left-handed vs. non-left-handed) ( 30980028) Handedness (Right-handed vs. non-right-handed) ( 30980028) Hemoglobin levels ( 32327693) Intelligence (MTAG) ( 29326435) Intraocular pressure ( 30054594) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Parkinson's disease ( 19915575 21812969) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Reaction time ( 29844566) Refractive error ( 32231278) Sense of smell ( 26632684) Thyroid stimulating hormone levels ( 30367059)
Interacting Genes		16 interacting genes: ATF5 BDKRB1 CCR8 CHFR CPEB2 DRD2 GABBR2 GNAO1 GPR37 JAKMIP1 KCNJ6 MAX NSF RGS4 SMO YWHAZ	28 interacting genes: ARRB1 ASPSCR1 CD28 CEP126 DRD2 EIF3E ERG28 ESR1 FUNDC2 GABARAP GABARAPL2 GABBR1 GABBR2 GOSR1 GRIA2 GRIA3 LUC7L2 MEOX2 NAPA NAPG PTPN9 RAMP3 RPLP1 STX1A STX4 STX8 USO1 VAPA
Entrez ID		2550	4905
HPRD ID		04644	03380
Ensembl ID		ENSG00000204681	ENSG00000073969
Uniprot IDs		A0A1U9X7R0 Q59HG8 Q5SUJ9 Q8IW08 Q9UBS5	A0A384MTI6 P46459
PDB IDs		4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6HKC 6UO8 6UO9 6UOA 6VJM 6W2X 6W2Y 6WIV 7C7Q 7C7S	6KZQ
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?