GABBR1 and ATF5

Data Source:
HPRD (two hybrid)

		GABBR1	ATF5
Description		gamma-aminobutyric acid type B receptor subunit 1	activating transcription factor 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Dendrite G Protein-coupled Receptor Heterodimeric Complex Presynaptic Membrane Postsynaptic Membrane Schaffer Collateral - CA1 Synapse GABA-ergic Synapse	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Centrosome Cytosol
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Tubulin Binding Kinase Binding Sequence-specific DNA Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Regulation Of Postsynaptic Membrane Potential Neuron-glial Cell Signaling	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Negative Regulation Of Cell Population Proliferation Post-embryonic Development Olfactory Bulb Interneuron Development Cerebellar Granule Cell Precursor Proliferation Multicellular Organism Growth Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centrosome Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Baclofen Progabide Taurine gamma-Aminobutyric acid SGS-742 Tezampanel Arbaclofen Arbaclofen Placarbil	Pseudoephedrine
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Brain morphology (MOSTest) ( 32665545) Crohn's disease ( 22412388) Fish- and plant-related diet ( 32066663) Height ( 28552196) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nasopharyngeal carcinoma ( 19664746) Nicotine dependence ( 28440896) Platelet count ( 26805783) Schizophrenia ( 27922604) Subcortical volume (MOSTest) ( 32665545) Ulna and radius bone mineral density ( 30172743) White blood cell count ( 27863252)
Interacting Genes		16 interacting genes: ATF5 BDKRB1 CCR8 CHFR CPEB2 DRD2 GABBR2 GNAO1 GPR37 JAKMIP1 KCNJ6 MAX NSF RGS4 SMO YWHAZ	17 interacting genes: ATXN1 CCDC6 CCND3 CDC34 CEBPA CEBPE CEBPG DISC1 EIF2B1 EP300 FBXO7 GABBR1 GABBR2 GIT2 GPS2 SYCE1L TTR
Entrez ID		2550	22809
HPRD ID		04644	05906
Ensembl ID		ENSG00000204681	ENSG00000169136
Uniprot IDs		A0A1U9X7R0 Q59HG8 Q5SUJ9 Q8IW08 Q9UBS5	A0A024QZG3 Q9Y2D1
PDB IDs		4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6HKC 6UO8 6UO9 6UOA 6VJM 6W2X 6W2Y 6WIV 7C7Q 7C7S
Enriched GO Terms of Interacting Partners?
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