FSHB and FSHR

Data Source:
HPRD (in vitro, in vivo)

		FSHB	FSHR
Description		follicle stimulating hormone subunit beta	follicle stimulating hormone receptor
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Follicle-stimulating Hormone Complex	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Receptor Complex
	Molecular Function	Hormone Activity Protein Binding Follicle-stimulating Hormone Activity	Follicle-stimulating Hormone Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity
	Biological Process	Progesterone Biosynthetic Process Transforming Growth Factor Beta Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Female Gamete Generation Female Pregnancy Positive Regulation Of Cell Population Proliferation Hormone-mediated Signaling Pathway Regulation Of Signaling Receptor Activity Positive Regulation Of Steroid Biosynthetic Process Peptide Hormone Processing Positive Regulation Of Cell Migration Follicle-stimulating Hormone Signaling Pathway Regulation Of Osteoclast Differentiation Positive Regulation Of Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Sertoli Cell Proliferation	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Spermatogenesis Female Gamete Generation Gonad Development Male Gonad Development Female Gonad Development Hormone-mediated Signaling Pathway Regulation Of Protein Kinase A Signaling Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Follicle-stimulating Hormone Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Follicle-stimulating Hormone Stimulus
Pathways		Glycoprotein hormones Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production	Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Menotropins Follitropin Urofollitropin Choriogonadotropin alfa Suramin Corifollitropin alfa
Diseases			Premature ovarian failure 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Ovarian hyperstimulation syndrome (OHSS)
GWAS		Body mass index ( 25673413) Endometriosis ( 28537267) Endometriosis or migraine ( 32121467) Length of menstrual cycle ( 26732621 30202859) Luteinizing hormone levels in polycystic ovary syndrome ( 26284813) Menarche (age at onset) ( 27182965 25231870) Menopause (age at onset) ( 26414677) Metabolite levels ( 23823483) Number of twin births ( 30760885) Polycystic ovary syndrome ( 26284813 30566500 26416764) Polycystic ovary syndrome (indeterminate subtype) ( 32574161) Polycystic ovary syndrome (reproductive subtype) ( 32574161) Refractive error ( 32231278) Sex hormone levels ( 26014426) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Spontaneous dizygotic twinning ( 27132594) Urate levels ( 31578528) Uterine fibroids ( 31649266)	Adverse response to chemotherapy (neutropenia/leucopenia) (etoposide) ( 23648065) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Cerebrospinal fluid t-tau levels in normal cognition ( 29274321) Chronotype ( 30696823) Depressive symptoms (SSRI exposure interaction) ( 25649181) Erectile dysfunction and prostate cancer treatment ( 20932654) Laterality in neovascular age-related macular degeneration ( 28775256) Lean body mass ( 28552196) Low density lipoprotein cholesterol levels ( 30498476) Lung cancer in ever smokers ( 28604730) Metabolite levels ( 23823483) Morning person ( 30696823) Plasma anti-thyroglobulin levels ( 29678681) Polycystic ovary syndrome ( 22885925 21151128) Radiation response ( 20923822) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482)
Interacting Genes		3 interacting genes: CGA CGB3 FSHR	20 interacting genes: AKT2 APPL1 ARR3 CANX CBX5 CGA FSHB GRK2 GRK4 GRK6 MT-RNR2 RPS27A S100A10 TOP1 TUG1 UBA52 UBB UBC YWHAQ ZBTB16
Entrez ID		2488	2492
HPRD ID		00644	00639
Ensembl ID		ENSG00000131808	ENSG00000170820
Uniprot IDs		A0A0F7RQE8 P01225	A0A1D5RMN4 P23945
PDB IDs		1FL7 1XWD 4AY9 4MQW	1XUN 1XWD 4AY9 4MQW
Enriched GO Terms of Interacting Partners?
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