PELI3 and RIPK2

Data Source:
BioGRID (enzymatic study)

		PELI3	RIPK2
Description		pellino E3 ubiquitin protein ligase family member 3	receptor interacting serine/threonine kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytoplasm Cytosol Cytoskeleton Vesicle Protein-containing Complex
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity JUN Kinase Kinase Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Signaling Receptor Binding Protein Binding ATP Binding LIM Domain Binding Identical Protein Binding Protein Homodimerization Activity CARD Domain Binding Caspase Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Polyubiquitination Toll Signaling Pathway Regulation Of Toll Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Activation Of MAPK Activity Positive Regulation Of Cytokine-mediated Signaling Pathway Adaptive Immune Response Positive Regulation Of T-helper 1 Type Immune Response Apoptotic Process Inflammatory Response Signal Transduction I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Activation Of JNKK Activity Activation Of JUN Kinase Activity Positive Regulation Of Peptidyl-threonine Phosphorylation Positive Regulation Of Cell Death Peptidyl-tyrosine Phosphorylation Positive Regulation Of Protein Ubiquitination Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Protein Binding Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Immature T Cell Proliferation Positive Regulation Of Peptidyl-serine Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 4 Signaling Pathway T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Innate Immune Response Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-12 Response To Interleukin-18 Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Activation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Xenophagy
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway Downstream TCR signaling p75NTR recruits signalling complexes TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs			Fostamatinib
Diseases
GWAS		Bipolar disorder ( 21926972)	Cerebral amyloid deposition (PET imaging) ( 26252872) Cognitive performance ( 20125193) Crohn's disease ( 23128233) Leprosy ( 20018961 27976721 25642632)
Interacting Genes		12 interacting genes: APP IRAK1 IRAK2 IRAK4 MAP3K14 MAP3K7 RIPK2 TRAF6 TRIM55 TRIM63 UBE2N UBE2V1	32 interacting genes: BCL10 BIRC2 BIRC3 CARD16 CARD6 CASP1 CASP8 CD40 CFLAR CHUK IKBKG IRAK1 KDM3A LRRK2 MAVS NGFR NOD1 NOD2 PELI3 PRMT2 SMAD4 SMURF1 TLR2 TLR4 TNFRSF1A TRAF1 TRAF2 TRAF5 TRAF6 UBE2I XIAP ZNRF4
Entrez ID		246330	8767
HPRD ID		17535	04585
Ensembl ID		ENSG00000174516	ENSG00000104312
Uniprot IDs		A0A024R5B1 A0A024R5I2 Q8N2H9	A0A0S2Z4Z8 O43353
PDB IDs			2N7Z 2N83 4C8B 5AR2 5AR3 5AR4 5AR5 5AR7 5AR8 5J79 5J7B 5NG0 5NG2 5NG3 5W5J 5W5O 5YRN 6ES0 6FU5 6GFJ 6GGS 6HMX 6RN8 6RNA 6S1F 6SZE 6SZJ 6UL8
Enriched GO Terms of Interacting Partners?
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