PELI3 and IRAK2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		PELI3	IRAK2
Description		pellino E3 ubiquitin protein ligase family member 3	interleukin 1 receptor associated kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Protein Polyubiquitination Toll Signaling Pathway Regulation Of Toll Signaling Pathway Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Activation Of MAPK Activity Regulation Of Cytokine-mediated Signaling Pathway Toll-like Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Cytokine-mediated Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Negative Regulation Of NF-kappaB Transcription Factor Activity Toll-like Receptor 9 Signaling Pathway Intracellular Signal Transduction Positive Regulation Of NF-kappaB Transcription Factor Activity Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1
Pathways		Interleukin-1 signaling IRAK1 recruits IKK complex IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation	MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane
Drugs
Diseases
GWAS		Bipolar disorder ( 21926972)	Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		12 interacting genes: APP IRAK1 IRAK2 IRAK4 MAP3K14 MAP3K7 RIPK2 TRAF6 TRIM55 TRIM63 UBE2N UBE2V1	20 interacting genes: ARAF HRAS IL1R1 IRAK1 IRAK3 MYD88 PELI1 PELI2 PELI3 SARM1 SMAD2 SMURF1 STT3A TARDBP TICAM2 TIRAP TLR4 TOLLIP TRAF6 ZC3H12A
Entrez ID		246330	3656
HPRD ID		17535	04491
Ensembl ID		ENSG00000174516	ENSG00000134070
Uniprot IDs		A0A024R5B1 A0A024R5I2 Q8N2H9	O43187
PDB IDs			3MOP
Enriched GO Terms of Interacting Partners?
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