ATP6V0D2 and RPS3

Data Source:
BioGRID (two hybrid)

		ATP6V0D2	RPS3
Description		ATPase H+ transporting V0 subunit d2	ribosomal protein S3
Image		No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Early Endosome Endosome Membrane Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Proton-transporting V-type ATPase, V0 Domain Plasma Membrane Proton-transporting V-type ATPase Complex Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Cytosol Ribosome Polysome Plasma Membrane Focal Adhesion Postsynaptic Density Membrane Cytosolic Small Ribosomal Subunit Ruffle Membrane Extracellular Exosome NF-kappaB Complex Mitotic Spindle Ribonucleoprotein Complex
	Molecular Function	Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Damaged DNA Binding RNA Binding MRNA Binding Structural Constituent Of Ribosome DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endodeoxyribonuclease Activity Protein Binding Microtubule Binding Transcription Factor Binding Tubulin Binding DNA N-glycosylase Activity Enzyme Binding Kinase Binding Protein Kinase Binding Hsp70 Protein Binding Oxidized Purine DNA Binding Oxidized Pyrimidine DNA Binding Ubiquitin-like Protein Conjugating Enzyme Binding Protein-containing Complex Binding Protein Kinase A Binding Iron-sulfur Cluster Binding Hsp90 Protein Binding Small Ribosomal Subunit RRNA Binding Supercoiled DNA Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Vacuolar Transport Vacuolar Acidification Insulin Receptor Signaling Pathway Regulation Of Macroautophagy Transferrin Transport Ion Transmembrane Transport Phagosome Acidification Proton Transmembrane Transport	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Apoptotic Process Cellular Response To DNA Damage Stimulus Chromosome Segregation Positive Regulation Of Gene Expression Negative Regulation Of Translation Viral Transcription Positive Regulation Of Microtubule Polymerization Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Ubiquitination Positive Regulation Of Endodeoxyribonuclease Activity Positive Regulation Of Interleukin-2 Production Cellular Response To Reactive Oxygen Species Positive Regulation Of Activated T Cell Proliferation DNA Damage Response, Detection Of DNA Damage Regulation Of Apoptotic Process Positive Regulation Of JUN Kinase Activity Negative Regulation Of DNA Repair Positive Regulation Of DNA Repair Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Assembly Cell Division Response To TNF Agonist Cellular Response To Hydrogen Peroxide Cellular Response To Tumor Necrosis Factor Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of DNA N-glycosylase Activity Positive Regulation Of Base-excision Repair Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		ROS and RNS production in phagocytes Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Tiludronic acid
Diseases
GWAS		Adverse response to lamotrigine and phenytoin ( 22379998) Neutrophil count ( 32888494)
Interacting Genes		20 interacting genes: ADRM1 AGO3 ARID5A CENPP CRX IKZF3 INCA1 MEOX2 NDUFB8 NICN1 PAX6 PHF12 POMC RBM15B REL RIBC1 RPS3 RUSC1 SEPTIN2 ZNF474	20 interacting genes: ATP6V0D2 CCT2 CSNK2A1 DDIT3 DUX4 FOLH1 HSP90AA1 IL7R LTV1 MDM2 NDRG1 NFKB1 PTEN RELA RPL9 SUMO1 SUMO2 UBC WBP2 YWHAQ
Entrez ID		245972	6188
HPRD ID		16522	10941
Ensembl ID		ENSG00000147614	ENSG00000149273
Uniprot IDs		A0A024R991 Q8N8Y2	P23396
PDB IDs			1WH9 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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