FLRT1 and MARK2

Data Source:
BioGRID (genetic interference)

		FLRT1	MARK2
Description		fibronectin leucine rich transmembrane protein 1	microtubule affinity regulating kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Focal Adhesion Cytoplasmic Vesicle Membrane Extracellular Matrix Cytoplasmic Vesicle Neuronal Cell Body Membrane Neuron Projection Terminus Perinuclear Region Of Cytoplasm	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle
	Molecular Function	Protein-macromolecule Adaptor Activity	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Cell Adhesion Fibroblast Growth Factor Receptor Signaling Pathway Dendrite Development Neuron Projection Extension	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding
Pathways		Downstream signaling of activated FGFR1
Drugs			Fostamatinib
Diseases
GWAS		Fruit consumption ( 32066663) Inflammatory bowel disease ( 23128233) Urate levels ( 31985003)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		1 interacting genes: GPR35	32 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 GAB1 GSK3B HDAC7 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L PARD3B PARD6A PINK1 PKD1 PRKCE PTPRD RAB11FIP2 RNF41 RPA2 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ
Entrez ID		23769	2011
HPRD ID		05311	02753
Ensembl ID		ENSG00000126500	ENSG00000072518
Uniprot IDs		A0A6E1VY70 Q9NZU1	A0A140VJP1 A8K2S4 Q7KZI7
PDB IDs			3IEC 5EAK 5KZ7 5KZ8
Enriched GO Terms of Interacting Partners?
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Tagcloud (Intersection) ?