CBLC and CKM

Data Source:
BioGRID (enzymatic study)

		CBLC	CKM
Description		Cbl proto-oncogene C	creatine kinase, M-type
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Raft	Extracellular Space Cytosol
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Protein Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity	Creatine Metabolic Process Phosphorylation Phosphocreatine Biosynthetic Process
Pathways			Creatine metabolism
Drugs			Creatine (Diaminomethyl-Methyl-Amino)-Acetic Acid D-arginine Phosphocreatine
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Apolipoprotein B levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 29875488) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Creatine kinase levels in statin users ( 25214527) Intelligence (MTAG) ( 29326435)
Interacting Genes		54 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 YES1 ZAP70	14 interacting genes: ASB9 CBLC CKB CKMT1A CKMT1B FHL2 HSPB2 MYOC MYOM2 NOS1AP TRIM54 TRIM55 TRIM63 YWHAQ
Entrez ID		23624	1158
HPRD ID		09765	00426
Ensembl ID		ENSG00000142273	ENSG00000104879
Uniprot IDs		Q9ULV8	B2R892 P06732
PDB IDs		3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR	1I0E
Enriched GO Terms of Interacting Partners?
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