RUSC1 and DOK6

Data Source:
BioGRID (two hybrid)

		RUSC1	DOK6
Description		RUN and SH3 domain containing 1	docking protein 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Microtubule Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Vesicle	Cytosol
	Molecular Function	Actin Binding Protein Binding	Protein Binding
	Biological Process	Protein Polyubiquitination	Axon Guidance
Pathways			RET signaling
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Bone fracture in osteoporosis ( 28580392) Caudate activity during reward ( 28927378) Mean platelet volume ( 31194788) Neonatal total 25-hydroxyvitamin D levels (maternal genetic effect) ( 32047095) Osteoporosis-related phenotypes ( 20548944) Platelet distribution width ( 32888494) Pursuit maintenance gain ( 29064472) Response to cytidine analogues (gemcitabine) ( 24483146) Skin aging (microtopography measurement) ( 28502801)
Interacting Genes		92 interacting genes: ABHD11 ABHD5 ABI2 AKAP8L ANKS1A APP ATP6V0D2 BPIFA1 C1orf109 CCDC120 CCDC57 CCHCR1 CCNC CDKN2B CMTM6 CREM CRYBA2 CTAG1A CTAG1B DMRT3 DOK6 DTX2 DVL2 EXOC8 EXOSC8 FAM9B FNDC3B GCM2 HMG20A HNRNPF INSC KCTD9 KRTAP19-1 KRTAP19-5 KRTAP6-2 KRTAP8-1 LIMS3 LIMS4 LMO2 MAGEA3 MAGEA6 MAGED1 MED25 MEIS2 MISP MOAP1 MORN3 MYOZ3 N4BP3 NICN1 NTAQ1 NTRK1 NUDT22 OIP5 P4HA3 PFDN5 PIK3R3 PLA2G6 PM20D2 PNMA1 POLR1C PRDM14 PRR35 RBPMS SMARCB1 SMYD1 SOHLH1 SPAG8 STUB1 SUOX TBC1D25 TCHP TEKT4 TENT5B TLE5 TRAPPC6A TRIM55 TRIM63 TRIM73 TSSK3 TTC19 TTC7B UFSP1 VGLL3 WWOX WWP2 ZIC1 ZMYND12 ZNF34 ZNF620 ZNF765 ZNF77	20 interacting genes: ABHD11 ARID5A C1orf94 CRYBB3 EGFR ERBB2 FAM86C1P LASP1 LGALS14 METTL27 NTRK3 PRR22 RBPMS RET RUSC1 SLC30A6 TBX15 TLE5 USP54 YPEL3
Entrez ID		23623	220164
HPRD ID		10206	13244
Ensembl ID		ENSG00000160753	ENSG00000206052
Uniprot IDs		B4DQB8 Q9BVN2	Q6PKX4
PDB IDs		4GIW
Enriched GO Terms of Interacting Partners?
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