RUSC1 and ABI2

Data Source:
BioGRID (two hybrid)

		RUSC1	ABI2
Description		RUN and SH3 domain containing 1	abl interactor 2
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GO Annotations	Cellular Component	Nucleus Early Endosome Golgi Apparatus Cytosol Microtubule Postsynaptic Density Microtubule Cytoskeleton Cytoplasmic Vesicle	Nucleus Cytoplasm Cytosol Cytoskeleton Adherens Junction Lamellipodium SCAR Complex Filopodium Tip Dendritic Spine
	Molecular Function	Actin Binding Protein Binding	Protein Binding Cytoskeletal Anchor Activity SH3 Domain Binding Kinase Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Signaling Adaptor Activity Identical Protein Binding Proline-rich Region Binding
	Biological Process	Protein Polyubiquitination	Cytoskeleton Organization Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Lamellipodium Assembly Viral Process Cell Migration Rac Protein Signal Transduction Peptidyl-tyrosine Phosphorylation Regulation Of Dendritic Spine Morphogenesis Lens Fiber Cell Morphogenesis Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways			Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Butyrylcholinesterase levels ( 21862451) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diverticular disease ( 30177863) Subclinical atherosclerosis traits (other) ( 17903303) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Trunk fat mass ( 28552196) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		92 interacting genes: ABHD11 ABHD5 ABI2 AKAP8L ANKS1A APP ATP6V0D2 BPIFA1 C1orf109 CCDC120 CCDC57 CCHCR1 CCNC CDKN2B CMTM6 CREM CRYBA2 CTAG1A CTAG1B DMRT3 DOK6 DTX2 DVL2 EXOC8 EXOSC8 FAM9B FNDC3B GCM2 HMG20A HNRNPF INSC KCTD9 KRTAP19-1 KRTAP19-5 KRTAP6-2 KRTAP8-1 LIMS3 LIMS4 LMO2 MAGEA3 MAGEA6 MAGED1 MED25 MEIS2 MISP MOAP1 MORN3 MYOZ3 N4BP3 NICN1 NTAQ1 NTRK1 NUDT22 OIP5 P4HA3 PFDN5 PIK3R3 PLA2G6 PM20D2 PNMA1 POLR1C PRDM14 PRR35 RBPMS SMARCB1 SMYD1 SOHLH1 SPAG8 STUB1 SUOX TBC1D25 TCHP TEKT4 TENT5B TLE5 TRAPPC6A TRIM55 TRIM63 TRIM73 TSSK3 TTC19 TTC7B UFSP1 VGLL3 WWOX WWP2 ZIC1 ZMYND12 ZNF34 ZNF620 ZNF765 ZNF77	197 interacting genes: ABI1 ABI3 ABL1 ABL2 ABLIM3 ADAM19 AKAP8L AKAP9 ANKRD55 ANKS1A ARHGAP32 ARMC7 ATP23 BAG4 BIN3 BLOC1S5 BLOC1S6 BORCS6 C19orf54 C1orf109 C1orf216 C20orf202 C4orf17 CCDC102B CCDC115 CCDC57 CCDC74B CCHCR1 CDK6 CENPH CENPQ CEP44 CEP57 CLPP COG3 CRX CUEDC1 DCTN2 DISC1 DLGAP2 DLGAP4 DNAI7 DTNB EFS EGLN3 EGR4 EIF3H ENAH ENKD1 EPS8L1 FAM161B FAM166B FAM214B FAM90A1 FAM9C FBXL19 FHL5 FKBP1A FOXD4L1 GAS2L2 GCC1 GFAP GGN GPANK1 HGS HHEX HNRNPK HOMER3 HSF2BP IFT20 IHO1 INCA1 INO80B INSYN1 KHDRBS1 KIAA1217 KIFC3 KNSTRN KRT13 KRT14 KRT15 KRT19 KRT20 KRT24 KRT27 KRT31 KRT33B KRT34 KRT36 KRT75 LENG1 LGALS9B LHX3 LHX8 LMO1 LMO2 LMO3 LMO4 LNX1 LURAP1 LZTS2 MAGEA1 MCM7 MED10 MED11 MED29 MEOX2 MRFAP1 MRFAP1L1 MRPL28 MRPL44 MYO15B MYOG MYOZ3 NCK1 NCK2 NCKIPSD NFASC NHSL2 NME4 NUP62 OIP5 OOEP PAK2 PCM1 PDLIM7 PFDN5 PHETA1 PHF1 PIN1 PLEKHN1 POMC PPIF PPP3CA PRAM1 PRDM14 PRDM6 PRKAA1 PRKAA2 PRR16 PRR20A PRR20B PRR20C PRR20D PRR20E PSMA1 PWWP2B RABEP1 RABGEF1 RASD1 RNPS1 RPP25 RSPH14 RUSC1 SCGN SDCBP SH3BP1 SH3KBP1 SLA SMARCB1 SMARCD1 SNAP23 SNAP91 SNAPIN SNX18 SNX7 SORBS3 STAM2 STX19 STX4 TFIP11 TLE5 TPM2 TRAF3IP1 TRIM32 TRIM72 TRIML2 TRIP6 UBQLN2 USHBP1 USP2 VARS2 VASP VCL VPS28 VPS37C WASF2 WASF3 WASHC1 WASHC3 WASL WIPF1 WWOX ZFP90 ZMYND12 ZNF474 ZNF688
Entrez ID		23623	10152
HPRD ID		10206	07338
Ensembl ID		ENSG00000160753	ENSG00000138443
Uniprot IDs		B4DQB8 Q9BVN2	A0A0C4DG21 A0A7D9NKC8 B7Z836 F8WAL6 Q9NYB9
PDB IDs		4GIW	2ED0 3P8C 4N78
Enriched GO Terms of Interacting Partners?
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