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MKRN1 and APC
Data Source:
BioGRID
(enzymatic study)
MKRN1
APC
Description
makorin ring finger protein 1
APC regulator of WNT signaling pathway
Image
No pdb structure
GO Annotations
Cellular Component
Cellular_component
Cytosol
Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Microtubule
Cytoplasmic Microtubule
Plasma Membrane
Adherens Junction
Bicellular Tight Junction
Lateral Plasma Membrane
Catenin Complex
Lamellipodium
Beta-catenin Destruction Complex
Ruffle Membrane
Perinuclear Region Of Cytoplasm
Wnt Signalosome
Molecular Function
RNA Binding
Protein Binding
Metal Ion Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Beta-catenin Binding
Microtubule Binding
Protein Kinase Regulator Activity
Protein Kinase Binding
Ubiquitin Protein Ligase Binding
Gamma-catenin Binding
Cadherin Binding
Microtubule Plus-end Binding
Dynein Complex Binding
Biological Process
Protein Polyubiquitination
Protein Ubiquitination
Mitotic Cytokinesis
Cell Fate Specification
Cellular Response To DNA Damage Stimulus
Negative Regulation Of Microtubule Depolymerization
Cell Cycle Arrest
Mitotic Spindle Assembly Checkpoint
Cell Adhesion
Pattern Specification Process
Nervous System Development
Negative Regulation Of Cell Population Proliferation
Insulin Receptor Signaling Pathway
Positive Regulation Of Cell Death
Wnt Signaling Pathway
Cell Migration
Protein Deubiquitination
Positive Regulation Of Cell Migration
Positive Regulation Of Pseudopodium Assembly
Regulation Of Microtubule-based Process
Positive Regulation Of Apoptotic Process
Regulation Of Cell Differentiation
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Protein-containing Complex Assembly
Bicellular Tight Junction Assembly
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Cold-induced Thermogenesis
Positive Regulation Of Protein Localization To Centrosome
Beta-catenin Destruction Complex Assembly
Beta-catenin Destruction Complex Disassembly
Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways
AKT phosphorylates targets in the cytosol
Regulation of PTEN stability and activity
Antigen processing: Ubiquitination & Proteasome degradation
Apoptotic cleavage of cellular proteins
Degradation of beta-catenin by the destruction complex
Beta-catenin phosphorylation cascade
Deactivation of the beta-catenin transactivating complex
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Disassembly of the destruction complex and recruitment of AXIN to the membrane
Signaling by GSK3beta mutants
S33 mutants of beta-catenin aren't phosphorylated
S37 mutants of beta-catenin aren't phosphorylated
S45 mutants of beta-catenin aren't phosphorylated
T41 mutants of beta-catenin aren't phosphorylated
APC truncation mutants are not K63 polyubiquitinated
APC truncation mutants have impaired AXIN binding
AXIN missense mutants destabilize the destruction complex
Truncations of AMER1 destabilize the destruction complex
Ovarian tumor domain proteases
Drugs
Diseases
Familial adenomatous polyposis
Esophageal cancer
Gastric cancer
Cancer of the anal canal
Gallbladder cancer
GWAS
General risk tolerance (MTAG) (
30643258
)
Gut microbiota relative abundance (unassigned genus belonging to family Lachnospiraceae) (
33208821
)
Immature fraction of reticulocytes (
32888494
)
Number of sexual partners (
30643258
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Body mass index (
29273807
)
Colorectal cancer or advanced adenoma (
30510241
)
Heel bone mineral density (
30598549
)
Reaction time (
29844566
)
Total body bone mineral density (
29304378
)
Interacting Genes
23 interacting genes:
APC
ASH2L
BYSL
CSNK1G1
DAXX
DUSP23
EXOSC8
FADD
FAM161A
MAP1LC3B
MTURN
NAA10
OTUB2
RAD23A
RAD23B
SDCBP
SLC13A1
UBASH3A
UBE2D1
UBE2D3
UBE2D4
UBE2W
YOD1
138 interacting genes:
ACTN1
ADGRL1
AGFG1
AGR3
ANKRD17
ANP32B
ANXA7
AP2B1
ARHGEF4
ASAP2
AXIN1
AXIN2
BAAT
BUB1
BUB1B
C4A
CASC3
CCL5
CGNL1
COG4
COG5
CREBBP
CSNK1A1
CSNK1E
CTBP1
CTNNA1
CTNNB1
CTSV
CYP17A1
CYTH2
DIRAS3
DKK3
DLG3
DLGAP1
DST
EPAS1
ERBIN
EXPH5
FAM214A
FANCC
FBP1
FBXO30
FHOD1
FLNA
GIGYF2
GOLGA2
GSK3B
HGS
HNRNPM
HOXC6
HSPA5
HTRA2
IL24
ING5
IQGAP1
JUP
KIAA1328
KIF5B
KIFAP3
KRT13
KRT14
KRT15
KRT17
KRT19
KRT23
KRT5
LAMA3
LAMA4
MACF1
MAP2K1
MAPRE1
MAPRE2
MBD5
MCM3AP
MKRN1
MT-ND4
MUC1
MYH10
MYH11
MYO6
NANS
NAT2
NAV1
NAV2
NAV3
NCKAP5
NCKAP5L
NEB
NOSTRIN
NUP153
NUP214
NUP42
NUP54
NUP58
NUP98
PDLIM2
PNISR
POM121
POM121C
PPP1R13B
PPP2CA
PPP2R5A
PPP3R2
PRKACA
PSMD1
PTPN13
RANBP9
RASA1
RBM4B
RP1
RPS27
SCRIB
SEC31A
SETDB1
SIAH1
SMAD1
SMC3
SNRNP200
SPECC1L
SPTBN1
SPTBN2
ST14
SYNE1
TAF1
TFAP2A
TFF1
TGFB1
TMEFF1
TMOD1
TPR
TRIM21
TRIM25
TSTD2
TUBA4A
XPO1
YWHAQ
ZNF106
ZNF510
Entrez ID
23608
324
HPRD ID
09673
01439
Ensembl ID
ENSG00000133606
ENSG00000134982
Uniprot IDs
Q9UHC7
P25054
Q4LE70
PDB IDs
1DEB
1EMU
1JPP
1M5I
1T08
1TH1
1V18
2RQU
3AU3
3NMW
3NMX
3NMZ
3QHE
3RL7
3RL8
3T7U
4G69
4YJE
4YJL
4YK6
5B6G
5IZ6
5IZ8
5IZ9
5IZA
5Z8H
Enriched GO Terms of Interacting Partners
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