TNFRSF13B and TNFSF13

Data Source:
HPRD (in vitro)

		TNFRSF13B	TNFSF13
Description		TNF receptor superfamily member 13B	TNF superfamily member 13
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane	Extracellular Region Extracellular Space Nucleoplasm Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Signaling Receptor Activity	Cytokine Activity Tumor Necrosis Factor Receptor Binding Receptor Ligand Activity
	Biological Process	B Cell Homeostasis Hematopoietic Progenitor Cell Differentiation Adaptive Immune Response Cell Surface Receptor Signaling Pathway Negative Regulation Of B Cell Proliferation Tumor Necrosis Factor-mediated Signaling Pathway	Immune Response Signal Transduction Positive Regulation Of Cell Population Proliferation Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of MRNA Stability Positive Regulation Of Isotype Switching To IgA Isotypes
Pathways		TNFs bind their physiological receptors	HuR (ELAVL1) binds and stabilizes mRNA TNFs bind their physiological receptors
Drugs
Diseases		Common variable immunodeficiency (CVID), including the following four diseases: Inducible T Cell costimulator (ICOS) defect; TACI defect; CD19 defect; BAFFR defect
GWAS		Albumin-globulin ratio ( 29403010) Apolipoprotein A1 levels ( 32203549) Diabetic retinopathy ( 21441570) Granulocyte percentage of myeloid white cells ( 27863252) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Hematological and biochemical traits ( 20139978) Hematology traits ( 23303382) IgG levels ( 22673310) Immunoglobulin light chain (AL) amyloidosis ( 28025584) Immunoglobulin measurement (zinc sulfate turbidity test) ( 29403010) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Multiple myeloma ( 32569378 26007630 23955597) Multiple myeloma and monoclonal gammopathy ( 26007630) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 22558069 29403010) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Red blood cell count ( 32888494) Reticulocyte count ( 32888494) Serum albumin level ( 29403010) Serum total protein level ( 23022100 29403010) Sodium levels ( 29403010) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494)	Albumin-globulin ratio ( 29403010) Bitter alcoholic beverage consumption ( 31046077) Brain morphology (MOSTest) ( 32665545) Chin dimples ( 27182965) Composite immunoglobulin trait (IgA x IgG x IgM) ( 28628107) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) IgA levels ( 22864923 28628107) IgA nephropathy ( 26028593 25305756 22197929) IgM levels ( 23118916) Myopia ( 27182965) Non-albumin protein levels ( 22558069 29403010) Serum total protein level ( 29403010) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		7 interacting genes: CAMLG SGTA TNFSF13 TNFSF13B TRAF2 TRAF5 TRAF6	13 interacting genes: CAMK1D FAS FURIN KRAS PIK3CA SDC2 SGTB TNFRSF11B TNFRSF13B TNFRSF14 TNFRSF17 TNFRSF1A TNFSF13B
Entrez ID		23495	8741
HPRD ID		05365	05128
Ensembl ID		ENSG00000240505	ENSG00000161955
Uniprot IDs		O14836 Q4ACX1	B3KR02 O75888 Q2QBA2
PDB IDs		1XU1 1XUT	4ZCH
Enriched GO Terms of Interacting Partners?
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