ICMT and RNF19B

Data Source:
BioGRID (two hybrid)

		ICMT	RNF19B
Description		isoprenylcysteine carboxyl methyltransferase	ring finger protein 19B
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Ubiquitin Ligase Complex Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Integral Component Of Membrane Cytolytic Granule
	Molecular Function	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity Protein Binding	Protein Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Cellular Protein Modification Process C-terminal Protein Methylation Protein Targeting To Membrane Post-translational Protein Modification	Protein Polyubiquitination Adaptive Immune Response Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Natural Killer Cell Mediated Cytotoxicity Protein Autoubiquitination
Pathways		Gamma carboxylation, hypusine formation and arylsulfatase activation RAS processing	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624 28270201)	Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269)
Interacting Genes		12 interacting genes: AQP6 ARL13B HRAS JAGN1 KCNJ6 MUC1 PDZK1IP1 RAC1 RAC2 RHOA RNF19B TRIM32	31 interacting genes: AP1M1 APOL3 ASGR1 CDIPT CLEC1A DHODH FDPS GIMAP5 GOSR2 ICMT MEST MFSD5 MS4A1 NIPAL4 PPP1CC RAP1GDS1 SACM1L SEC22A SEC23A SELENOK SLC30A3 TAP1 TMEM100 TMEM120B TMEM208 TMEM31 TNF TSPAN2 UBE2D2 UBE2D3 UBE2L3
Entrez ID		23463	127544
HPRD ID		09321	13725
Ensembl ID		ENSG00000116237	ENSG00000116514
Uniprot IDs		A0A024R4F6 B3KS61 O60725	Q6ZMZ0
PDB IDs
Enriched GO Terms of Interacting Partners?
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