ICMT and PDZK1IP1

Data Source:
BioGRID (two hybrid)

		ICMT	PDZK1IP1
Description		isoprenylcysteine carboxyl methyltransferase	PDZK1 interacting protein 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane	Integral Component Of Membrane Extracellular Exosome
	Molecular Function	Protein C-terminal Carboxyl O-methyltransferase Activity Protein C-terminal S-isoprenylcysteine Carboxyl O-methyltransferase Activity Protein Binding	Protein Binding
	Biological Process	Cellular Protein Modification Process C-terminal Protein Methylation Protein Targeting To Membrane Post-translational Protein Modification
Pathways		Gamma carboxylation, hypusine formation and arylsulfatase activation RAS processing
Drugs
Diseases
GWAS		Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Resting heart rate ( 27798624 28270201)	Clozapine-induced agranulocytosis ( 25187353)
Interacting Genes		12 interacting genes: AQP6 ARL13B HRAS JAGN1 KCNJ6 MUC1 PDZK1IP1 RAC1 RAC2 RHOA RNF19B TRIM32	77 interacting genes: AGR3 AIG1 APOA2 APOD AQP2 AQP6 ARL13B ASGR1 C14orf180 C2CD2L CD81 CES1 CLDN19 COPS6 CYB5B CYBC1 EMC6 ERG28 FAM3C FCER1G GALNT15 GAST GIMAP5 GRM2 GYPA HMOX1 ICMT IGFBP5 JAGN1 LEPROTL1 LHFPL5 MIP MYADM MYADML2 NSG1 NUMB PDZK1 PEX16 PGAP2 PLP2 PLPP4 PLPP6 PMP22 RPRM RTP2 SDCBP SFTPC SFXN2 SLC22A1 SLC22A2 SLC35B1 SLC35B4 STRIT1 STX12 THBD TMEM101 TMEM107 TMEM109 TMEM11 TMEM140 TMEM14A TMEM14B TMEM14C TMEM203 TMEM39B TMEM65 TMEM86A TMEM97 TNFRSF10C TRARG1 TRIM54 TSPO2 UPK1B UTP14A VAMP3 YIPF6 ZDHHC17
Entrez ID		23463	10158
HPRD ID		09321	06211
Ensembl ID		ENSG00000116237	ENSG00000162366
Uniprot IDs		A0A024R4F6 B3KS61 O60725	Q13113
PDB IDs
Enriched GO Terms of Interacting Partners?
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