SLC44A1 and KCNE3

Data Source:
BioGRID (two hybrid)

		SLC44A1	KCNE3
Description		solute carrier family 44 member 1	potassium voltage-gated channel subfamily E regulatory subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Plasma Membrane Membrane Integral Component Of Membrane Extracellular Exosome	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Vesicle Neuronal Cell Body Membrane Perikaryon Membrane Raft
	Molecular Function	Choline Transmembrane Transporter Activity Transmembrane Transporter Activity	Delayed Rectifier Potassium Channel Activity Protein Binding Potassium Channel Regulator Activity Ion Channel Binding Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Phosphatidylcholine Biosynthetic Process Choline Transport Choline Catabolic Process Transmembrane Transport Transport Across Blood-brain Barrier	Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ventricular Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Regulation Of Heart Rate By Cardiac Conduction Potassium Ion Export Across Plasma Membrane Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Voltage-gated Calcium Channel Activity Negative Regulation Of Delayed Rectifier Potassium Channel Activity Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Voltage-gated Potassium Channel Activity Negative Regulation Of Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential
Pathways		Synthesis of PC Transport of bile salts and organic acids, metal ions and amine compounds Choline catabolism	Phase 3 - rapid repolarisation Phase 2 - plateau phase
Drugs			Enflurane Promethazine Miconazole
Diseases			Brugada syndrome (BRS)
GWAS		Aluminium levels ( 26025379) Behavioral disturbance or psychiatric symptoms in prion disease ( 25897833) Glaucoma ( 30104761) Intraocular pressure ( 29617998 30591961) Lung cancer in ever smokers ( 28604730) Menarche (age at onset) ( 19448620) Response to fenofibrate (total cholesterol levels) ( 27002377)	Corneal astigmatism ( 22144915) Neuritic plaque ( 31497858)
Interacting Genes		3 interacting genes: C11orf58 KCNE3 NUDT21	10 interacting genes: C11orf68 EEF1A1 GAPDH GOLM1 KIF5A LRIF1 POLA2 QARS1 RASSF1 SLC44A1
Entrez ID		23446	10008
HPRD ID		16197	07256
Ensembl ID		ENSG00000070214	ENSG00000175538
Uniprot IDs		A0A024R151 Q8WWI5	Q6IAE6 Q9Y6H6
PDB IDs			2NDJ 6V00 6V01
Enriched GO Terms of Interacting Partners?
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