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ITGB3BP and CCNA2
Data Source:
HPRD
(in vitro, two hybrid, in vivo)
ITGB3BP
CCNA2
Description
integrin subunit beta 3 binding protein
cyclin A2
Image
No pdb structure
GO Annotations
Cellular Component
Condensed Chromosome Kinetochore
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Membrane
Cyclin-dependent Protein Kinase Holoenzyme Complex
Female Pronucleus
Male Pronucleus
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cyclin A2-CDK2 Complex
Molecular Function
Protein Binding
Protein C-terminus Binding
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Protein Kinase Binding
Protein Domain Specific Binding
Biological Process
Regulation Of Transcription, DNA-templated
Apoptotic Process
Cell Cycle
Cell Adhesion
Signal Transduction
CENP-A Containing Nucleosome Assembly
Positive Regulation Of Apoptotic Process
Cell Division
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
G2/M Transition Of Mitotic Cell Cycle
Regulation Of DNA Replication
Ras Protein Signal Transduction
Viral Process
Histone Phosphorylation
Protein Deubiquitination
Animal Organ Regeneration
Response To Glucagon
Cellular Response To Platelet-derived Growth Factor Stimulus
Cellular Response To Leptin Stimulus
Mitotic Cell Cycle Phase Transition
Cell Cycle G1/S Phase Transition
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fibroblast Proliferation
Cell Division
Cellular Response To Cocaine
Cellular Response To Luteinizing Hormone Stimulus
Cellular Response To Estradiol Stimulus
Cellular Response To Hypoxia
Cellular Response To Nitric Oxide
Cochlea Development
Cellular Response To Insulin-like Growth Factor Stimulus
Pathways
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
NRIF signals cell death from the nucleus
NRIF signals cell death from the nucleus
Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Deposition of new CENPA-containing nucleosomes at the centromere
Mitotic Prometaphase
EML4 and NUDC in mitotic spindle formation
Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Drugs
4-(2,4-Dimethyl-Thiazol-5-Yl)-Pyrimidin-2-Ylamine
6-O-Cyclohexylmethyl Guanine
[4-(2-Amino-4-Methyl-Thiazol-5-Yl)-Pyrimidin-2-Yl]-(3-Nitro-Phenyl)-Amine
4-(2,4-Dimethyl-1,3-thiazol-5-yl)-N-[4-(trifluoromethyl)phenyl]-2-pyrimidinamine
4-[(7-OXO-7H-THIAZOLO[5,4-E]INDOL-8-YLMETHYL)-AMINO]-N-PYRIDIN-2-YL-BENZENESULFONAMIDE
N-(3-cyclopropyl-1H-pyrazol-5-yl)-2-(2-naphthyl)acetamide
2-ANILINO-6-CYCLOHEXYLMETHOXYPURINE
O6-CYCLOHEXYLMETHOXY-2-(4'-SULPHAMOYLANILINO) PURINE
(2S)-N-[(3E)-5-Cyclopropyl-3H-pyrazol-3-ylidene]-2-[4-(2-oxo-1-imidazolidinyl)phenyl]propanamide
N-cyclopropyl-4-pyrazolo[1,5-b]pyridazin-3-ylpyrimidin-2-amine
6-CYCLOHEXYLMETHOXY-2-(3'-CHLOROANILINO) PURINE
5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]-2-FURYL}-N-METHYLBENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}-2-(TRIFLUOROMETHYL)BENZENESULFONAMIDE
4-{5-[(Z)-(2-IMINO-4-OXO-1,3-THIAZOLIDIN-5-YLIDENE)METHYL]FURAN-2-YL}BENZOIC ACID
N-[4-(2,4-DIMETHYL-THIAZOL-5-YL)-PYRIMIDIN-2-YL]-N',N'-DIMETHYL-BENZENE-1,4-DIAMINE
4-{[5-(CYCLOHEXYLOXY)[1,2,4]TRIAZOLO[1,5-A]PYRIMIDIN-7-YL]AMINO}BENZENESULFONAMIDE
1-(3,5-DICHLOROPHENYL)-5-METHYL-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID
4-(4-methoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
4-(4-propoxy-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-2-amine
HYDROXY(OXO)(3-{[(2Z)-4-[3-(1H-1,2,4-TRIAZOL-1-YLMETHYL)PHENYL]PYRIMIDIN-2(5H)-YLIDENE]AMINO}PHENYL)AMMONIUM
4-Methyl-5-[(2Z)-2-{[4-(4-morpholinyl)phenyl]imino}-2,5-dihydro-4-pyrimidinyl]-1,3-thiazol-2-amine
6-CYCLOHEXYLMETHYLOXY-2-(4'-HYDROXYANILINO)PURINE
4-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)--BENZAMIDE
3-(6-CYCLOHEXYLMETHOXY-9H-PURIN-2-YLAMINO)-BENZENESULFONAMIDE
(2R)-2-{[4-(benzylamino)-8-(1-methylethyl)pyrazolo[1,5-a][1,3,5]triazin-2-yl]amino}butan-1-ol
3-({2-[(4-{[6-(CYCLOHEXYLMETHOXY)-9H-PURIN-2-YL]AMINO}PHENYL)SULFONYL]ETHYL}AMINO)PROPAN-1-OL
1-methyl-8-(phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxylic acid
(2R)-2-({9-(1-methylethyl)-6-[(4-pyridin-2-ylbenzyl)amino]-9H-purin-2-yl}amino)butan-1-ol
1-[4-(AMINOSULFONYL)PHENYL]-1,6-DIHYDROPYRAZOLO[3,4-E]INDAZOLE-3-CARBOXAMIDE
4-{[4-AMINO-6-(CYCLOHEXYLMETHOXY)-5-NITROSOPYRIMIDIN-2-YL]AMINO}BENZAMIDE
Variolin B
Diseases
GWAS
Mean spheric corpuscular volume (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Interacting Genes
41 interacting genes:
ACTN2
ANKRD11
APP
ARFIP2
C14orf119
CCNA2
CERT1
DDX24
EFHC1
ESR1
GTPBP3
HSF2BP
ITGB3
ITGB5
KDM1A
KIAA0930
KIFC3
LRRK2
MAPK6
MAPK9
MEIS2
MEOX2
MSGN1
MTA1
NFKB1
NRDE2
NTAQ1
PBX3
PIH1D2
PIK3R3
RECQL5
RXRA
RXRG
SNAPC5
SUOX
SVIL
THRA
TRIML2
UBR7
USHBP1
USP20
49 interacting genes:
ARID4A
BRCA1
BRCA2
BTG1
BUB1B
CALM1
CDC20
CDC25C
CDC6
CDK1
CDK2
CDK3
CDKN1A
CDKN1B
CDT1
DTNBP1
E2F1
E2F3
FANCC
FEN1
H1-1
H1-5
HERC5
HIRA
ITGB3BP
KAT2B
MAD2L1
MAGEA11
MYBL2
NFYA
PGR
POLA1
PRC1
PSMD4
PTMA
RAD23A
RB1
RBL1
RBL2
RPA1
SKP1
SKP2
SP1
TAF1
TP53
TRAF3IP1
UBE2C
UBTF
USP37
Entrez ID
23421
890
HPRD ID
09267
00453
Ensembl ID
ENSG00000142856
ENSG00000145386
Uniprot IDs
D3DQ59
Q13352
P20248
PDB IDs
1E9H
1FIN
1FVV
1GY3
1H1P
1H1Q
1H1R
1H1S
1H24
1H25
1H26
1H27
1H28
1JST
1JSU
1OGU
1OI9
1OIU
1OIY
1OKV
1OKW
1OL1
1OL2
1P5E
1PKD
1QMZ
1URC
1VYW
2BKZ
2BPM
2C4G
2C5N
2C5O
2C5V
2C5X
2C6T
2CCH
2CCI
2CJM
2I40
2IW6
2IW8
2IW9
2UUE
2UZB
2UZD
2UZE
2UZL
2V22
2WEV
2WFY
2WHB
2WIH
2WIP
2WMA
2WMB
2WPA
2WXV
2X1N
3EID
3EJ1
3EOC
3F5X
4BCK
4BCM
4BCN
4BCP
4CFM
4CFN
4CFU
4CFV
4CFW
4CFX
4EOI
4EOJ
4EOK
4EOL
4EOM
4EON
4EOO
4EOP
4EOQ
4EOR
4EOS
4FX3
5CYI
5IF1
5LMK
5NEV
6ATH
6GVA
6P3W
6Q6G
6Q6H
6RIJ
Enriched GO Terms of Interacting Partners
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