SIRT4 and SKP2

Data Source:
BioGRID (pull down)

		SIRT4	SKP2
Description		sirtuin 4	S-phase kinase associated protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Nucleus Nucleoplasm Nucleolus Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	NAD+ ADP-ribosyltransferase Activity Protein Binding Zinc Ion Binding NAD-dependent Protein Deacetylase Activity Biotinidase Activity Lipoamidase Activity NAD+ Binding	Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Glutamine Family Amino Acid Metabolic Process Protein ADP-ribosylation Glutamine Metabolic Process Cellular Response To DNA Damage Stimulus Mitochondrion Organization Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-lysine Deacetylation Negative Regulation Of Fatty Acid Oxidation Negative Regulation Of Insulin Secretion Positive Regulation Of Lipid Biosynthetic Process Cellular Response To Hypoxia Tricarboxylic Acid Metabolic Process Negative Regulation Of Protein Processing Involved In Protein Targeting To Mitochondrion Regulation Of Pyruvate Dehydrogenase Activity	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Protein Polyubiquitination Viral Process Protein Deubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Innate Immune Response Defense Response To Virus Regulation Of Cell Cycle Protein K48-linked Ubiquitination
Pathways		Transcriptional activation of mitochondrial biogenesis	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 SCF(Skp2)-mediated degradation of p27/p21 Ub-specific processing proteases Orc1 removal from chromatin Cyclin D associated events in G1 Regulation of RUNX2 expression and activity Neddylation Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Birth weight ( 31043758) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Red cell distribution width ( 32888494 27863252)
Interacting Genes		2 interacting genes: PTEN SKP2	64 interacting genes: AKT1 BRAP BRCA1 BTG1 BTG2 CCNA2 CCNE1 CCNT1 CDC14B CDC34 CDH1 CDK2 CDK9 CDKN1A CDKN1B CDKN1C CDT1 CEBPA CHKA CKS1B CKS1BP7 CUL1 CUL4A DDB1 DUSP1 E2F1 ELF4 EP300 ESR1 FZR1 GPS1 KPNA1 KPNA6 MEF2D MTOR MYB MYBL2 MYC NLK ORC1 PAX8 PDCD4 PFDN1 PIM1 POLR2A PSMD9 RAG2 RB1 RBL2 RND3 SIRT4 SIRT6 SKP1 SLC9A3R1 SMAD4 SQSTM1 TAL1 TCF3 TRIM21 UBB VHL WEE1 YWHAB YY1
Entrez ID		23409	6502
HPRD ID		06837	03256
Ensembl ID		ENSG00000089163	ENSG00000145604
Uniprot IDs		Q9Y6E7	A0A024R069 Q13309
PDB IDs			1FQV 1FS1 1FS2 1LDK 2ASS 2AST
Enriched GO Terms of Interacting Partners?
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