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SKP2 and NLK
Data Source:
HPRD
(in vivo)
SKP2
NLK
Description
S-phase kinase associated protein 2
nemo like kinase
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytosol
SCF Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Molecular Function
Protein Binding
Identical Protein Binding
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
MAP Kinase Activity
Protein Binding
ATP Binding
Transcription Factor Binding
Ubiquitin Protein Ligase Binding
SH2 Domain Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Viral Process
Protein Deubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Innate Immune Response
Defense Response To Virus
Regulation Of Cell Cycle
Protein K48-linked Ubiquitination
MAPK Cascade
Regulation Of Transcription, DNA-templated
Protein Phosphorylation
Transforming Growth Factor Beta Receptor Signaling Pathway
Wnt Signaling Pathway, Calcium Modulating Pathway
Peptidyl-threonine Phosphorylation
Negative Regulation Of Wnt Signaling Pathway
Intracellular Signal Transduction
Serine Phosphorylation Of STAT Protein
Protein Autophosphorylation
Protein Stabilization
Pathways
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
SCF(Skp2)-mediated degradation of p27/p21
Ub-specific processing proteases
Orc1 removal from chromatin
Cyclin D associated events in G1
Regulation of RUNX2 expression and activity
Neddylation
Aberrant regulation of mitotic exit in cancer due to RB1 defects
Antigen processing: Ubiquitination & Proteasome degradation
Ca2+ pathway
Drugs
Diseases
GWAS
Birth weight (
31043758
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Red cell distribution width (
32888494
27863252
)
Non-response to bupropion and depression (
27622933
)
Interacting Genes
64 interacting genes:
AKT1
BRAP
BRCA1
BTG1
BTG2
CCNA2
CCNE1
CCNT1
CDC14B
CDC34
CDH1
CDK2
CDK9
CDKN1A
CDKN1B
CDKN1C
CDT1
CEBPA
CHKA
CKS1B
CKS1BP7
CUL1
CUL4A
DDB1
DUSP1
E2F1
ELF4
EP300
ESR1
FZR1
GPS1
KPNA1
KPNA6
MEF2D
MTOR
MYB
MYBL2
MYC
NLK
ORC1
PAX8
PDCD4
PFDN1
PIM1
POLR2A
PSMD9
RAG2
RB1
RBL2
RND3
SIRT4
SIRT6
SKP1
SLC9A3R1
SMAD4
SQSTM1
TAL1
TCF3
TRIM21
UBB
VHL
WEE1
YWHAB
YY1
25 interacting genes:
ASGR1
ATXN1
CREBBP
CUL1
FBXW5
FOXO4
FOXP3
GRN
HIPK2
KRTAP10-1
KRTAP10-3
KRTAP4-2
KRTAP5-6
KRTAP5-9
LEF1
MYB
MYBL1
NDOR1
QRICH1
RCHY1
SDR16C5
SKP2
STAT3
USP4
ZHX3
Entrez ID
6502
51701
HPRD ID
03256
17637
Ensembl ID
ENSG00000145604
ENSG00000087095
Uniprot IDs
A0A024R069
Q13309
A0A024QZ12
Q9UBE8
PDB IDs
1FQV
1FS1
1FS2
1LDK
2ASS
2AST
Enriched GO Terms of Interacting Partners
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Tagcloud
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Tagcloud (Difference)
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Tagcloud (Intersection)
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