COTL1 and BBS5

Data Source:
BioGRID (affinity chromatography technology)

		COTL1	BBS5
Description		coactosin like F-actin binding protein 1	Bardet-Biedl syndrome 5
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GO Annotations	Cellular Component	Extracellular Region Nucleus Cytosol Actin Filament Plasma Membrane Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen	Cytosol Axoneme Centriolar Satellite BBSome Ciliary Basal Body Ciliary Membrane
	Molecular Function	Actin Binding Protein Binding Enzyme Binding Actin Filament Binding	RNA Polymerase II Repressing Transcription Factor Binding Protein Binding Phosphatidylinositol-3-phosphate Binding
	Biological Process	Biological_process Regulation Of Actin Filament Polymerization Neutrophil Degranulation Defense Response To Fungus	Heart Looping Visual Perception Protein Transport Melanosome Transport Motile Cilium Assembly Intracellular Transport Response To Stimulus Cilium Assembly
Pathways		Neutrophil degranulation	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Carotid intima media thickness x smoking interaction ( 32117412) Cleft lip with or without cleft palate (maternal periconceptional vitamin use interaction) ( 29535761) Cocaine dependence ( 31212010) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Heel bone mineral density ( 30598549) Macular thickness ( 30535121)	Iris heterochromicity ( 30895295)
Interacting Genes		6 interacting genes: ACTA1 ACTB ACTG1 ALOX5 PDE6H TERF2IP	2 interacting genes: CRADD KLC3
Entrez ID		23406	129880
HPRD ID		09482	10353
Ensembl ID		ENSG00000103187	ENSG00000163093
Uniprot IDs		A0A384MTY2 Q14019	A0A0S2Z626 Q8N3I7
PDB IDs		1T2L 1T3X 1T3Y 1TMW 1VFQ 1WNJ	6XTB
Enriched GO Terms of Interacting Partners?
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