EXOSC2 and COLEC12

Data Source:
BioGRID (affinity chromatography technology)

		EXOSC2	COLEC12
Description		exosome component 2	collectin subfamily member 12
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GO Annotations	Cellular Component	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol	Collagen Trimer Extracellular Space Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Membrane Extracellular Matrix
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding	Scavenger Receptor Activity Galactose Binding Low-density Lipoprotein Particle Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing	Receptor-mediated Endocytosis Phagocytosis, Recognition Defense Response Carbohydrate Mediated Signaling Toll-like Receptor 3 Signaling Pathway Defense Response To Bacterium Innate Immune Response Regulation Of Immune Response Positive Regulation Of Cell Adhesion Molecule Production Cellular Response To Exogenous DsRNA
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Scavenging by Class A Receptors
Drugs
Diseases
GWAS			Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Blood protein levels ( 30072576 29875488) Coenzyme Q10 levels ( 27149984) Metabolic syndrome ( 29212154) Obesity-related traits ( 23251661) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		18 interacting genes: DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 GALNT13 KHSRP MRPL48 MTREX PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 ZNF408	3 interacting genes: APP EXOC1 FBXO7
Entrez ID		23404	81035
HPRD ID		03758	06358
Ensembl ID		ENSG00000130713	ENSG00000158270
Uniprot IDs		B3KQW2 Q13868	Q5KU26
PDB IDs		2NN6 6D6Q 6D6R 6H25	2OX8
Enriched GO Terms of Interacting Partners?
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