UBR4 and SRGN

Data Source:
BioGRID (two hybrid)

		UBR4	SRGN
Description		ubiquitin protein ligase E3 component n-recognin 4	serglycin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Centrosome Cytosol Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Extracellular Space Golgi Apparatus Secretory Granule Platelet Alpha Granule Lumen Mast Cell Granule Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Postsynaptic Specialization, Intracellular Component
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Calmodulin Binding Zinc Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination Neutrophil Degranulation	Negative Regulation Of Cytokine Production Platelet Degranulation Apoptotic Process Protein Processing Negative Regulation Of Bone Mineralization Biomineral Tissue Development Secretory Granule Organization Mast Cell Secretory Granule Organization T Cell Secretory Granule Organization Maintenance Of Protease Location In Mast Cell Secretory Granule Maintenance Of Granzyme B Location In T Cell Secretory Granule Modulation Of Chemical Synaptic Transmission Regulation Of Postsynapse Organization Granzyme-mediated Programmed Cell Death Signaling Pathway
Pathways		Neutrophil degranulation Antigen processing: Ubiquitination & Proteasome degradation	Platelet degranulation
Drugs		Verpasep caltespen PCL-016
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Composite immunoglobulin trait (IgA/IgG) ( 28628107)	Glycemic traits (pregnancy) ( 23903356) Hemoglobin levels ( 32327693)
Interacting Genes		13 interacting genes: ADRA1A AGTR1 CALM1 ERG MTNR1A MTNR1B PRPF40A SRGN SRPK2 SUMO2 UBC UBE2D2 UBE2L3	17 interacting genes: ALB BAG6 CCL3 CD44 CEP70 FHL3 GZMB NCALD PEX12 PF4 PSRC1 SGTA SGTB UBQLN1 UBQLN2 UBQLN4 UBR4
Entrez ID		23352	5552
HPRD ID		10184	01513
Ensembl ID		ENSG00000127481	ENSG00000122862
Uniprot IDs		Q5T4S7	P10124
PDB IDs
Enriched GO Terms of Interacting Partners?
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