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GRB2 and UBA52
Data Source:
BioGRID
(two hybrid)
GRB2
UBA52
Description
growth factor receptor bound protein 2
ubiquitin A-52 residue ribosomal protein fusion product 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Endosome
Golgi Apparatus
Cytosol
Plasma Membrane
Cell-cell Junction
COP9 Signalosome
Vesicle Membrane
Extracellular Exosome
Grb2-EGFR Complex
Extracellular Space
Nucleus
Nucleoplasm
Cytoplasm
Mitochondrial Outer Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
Plasma Membrane
Endosome Membrane
Cytosolic Small Ribosomal Subunit
Endocytic Vesicle Membrane
Vesicle
Host Cell
Extracellular Exosome
Molecular Function
Phosphotyrosine Residue Binding
RNA Binding
Epidermal Growth Factor Receptor Binding
Neurotrophin TRKA Receptor Binding
Protein Binding
SH3 Domain Binding
Protein Kinase Binding
Protein Phosphatase Binding
Protein-macromolecule Adaptor Activity
Identical Protein Binding
Insulin Receptor Substrate Binding
Protein-containing Complex Binding
Ephrin Receptor Binding
Structural Constituent Of Ribosome
Protein Binding
Protein Tag
Ubiquitin Protein Ligase Binding
Biological Process
MAPK Cascade
Epidermal Growth Factor Receptor Signaling Pathway
Ras Protein Signal Transduction
Axon Guidance
Aging
Insulin Receptor Signaling Pathway
Fibroblast Growth Factor Receptor Signaling Pathway
Viral Process
Cytokine-mediated Signaling Pathway
Positive Regulation Of Actin Filament Polymerization
T Cell Costimulation
Actin Cytoskeleton Reorganization
Receptor Internalization
Entry Of Bacterium Into Host Cell
Interleukin-15-mediated Signaling Pathway
Fc-epsilon Receptor Signaling Pathway
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
ERBB2 Signaling Pathway
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of MAPK Cascade
Positive Regulation Of Ras Protein Signal Transduction
Neurotrophin TRK Receptor Signaling Pathway
Anatomical Structure Formation Involved In Morphogenesis
Leukocyte Migration
Positive Regulation Of Protein Kinase B Signaling
Branching Involved In Labyrinthine Layer Morphogenesis
Membrane Organization
Cellular Response To Ionizing Radiation
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Negative Regulation Of Transcription By RNA Polymerase II
Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay
Activation Of MAPK Activity
Protein Polyubiquitination
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
MyD88-dependent Toll-like Receptor Signaling Pathway
MyD88-independent Toll-like Receptor Signaling Pathway
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Translational Initiation
Cellular Protein Modification Process
SRP-dependent Cotranslational Protein Targeting To Membrane
Protein Targeting To Peroxisome
Transforming Growth Factor Beta Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
JNK Cascade
Wnt Signaling Pathway
Endosomal Transport
Protein Ubiquitination
Protein Deubiquitination
Viral Life Cycle
Virion Assembly
Viral Transcription
Cytokine-mediated Signaling Pathway
Modification-dependent Protein Catabolic Process
Translesion Synthesis
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Anaphase-promoting Complex-dependent Catabolic Process
Nucleotide-excision Repair, DNA Incision
TRIF-dependent Toll-like Receptor Signaling Pathway
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of MRNA Stability
Cellular Protein Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of NF-kappaB Transcription Factor Activity
Stress-activated MAPK Cascade
Transmembrane Transport
Membrane Organization
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Global Genome Nucleotide-excision Repair
Error-free Translesion Synthesis
Intracellular Transport Of Virus
Pathways
Interleukin-15 signaling
Interleukin-15 signaling
STAT5 activation downstream of FLT3 ITD mutants
Signaling by FLT3 ITD and TKD mutants
Signaling by FLT3 ITD and TKD mutants
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Activation of NF-kappaB in B cells
ISG15 antiviral mechanism
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants
ER-Phagosome pathway
Downregulation of ERBB4 signaling
Spry regulation of FGF signaling
Downregulation of ERBB2:ERBB3 signaling
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
Budding and maturation of HIV virion
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
DDX58/IFIH1-mediated induction of interferon-alpha/beta
APC/C:Cdc20 mediated degradation of Cyclin B
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Membrane binding and targetting of GAG proteins
Assembly Of The HIV Virion
APC-Cdc20 mediated degradation of Nek2A
SRP-dependent cotranslational protein targeting to membrane
SRP-dependent cotranslational protein targeting to membrane
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
EGFR downregulation
SCF(Skp2)-mediated degradation of p27/p21
Viral mRNA Translation
Degradation of beta-catenin by the destruction complex
TCF dependent signaling in response to WNT
Downstream TCR signaling
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
Regulation of activated PAK-2p34 by proteasome mediated degradation
NOTCH1 Intracellular Domain Regulates Transcription
Activated NOTCH1 Transmits Signal to the Nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Downregulation of TGF-beta receptor signaling
Downregulation of TGF-beta receptor signaling
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
Selenocysteine synthesis
Separation of Sister Chromatids
Oxidative Stress Induced Senescence
Senescence-Associated Secretory Phenotype (SASP)
Oncogene Induced Senescence
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Stimuli-sensing channels
Constitutive Signaling by NOTCH1 HD Domain Mutants
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
Regulation of innate immune responses to cytosolic DNA
Glycogen synthesis
Autodegradation of the E3 ubiquitin ligase COP1
Deactivation of the beta-catenin transactivating complex
Myoclonic epilepsy of Lafora
ABC-family proteins mediated transport
Circadian Clock
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Regulation of FZD by ubiquitination
PINK1-PRKN Mediated Mitophagy
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Hedgehog 'on' state
Negative regulation of FGFR1 signaling
Negative regulation of FGFR2 signaling
Negative regulation of FGFR3 signaling
Negative regulation of FGFR4 signaling
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
Negative regulation of MAPK pathway
Regulation of necroptotic cell death
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAP3K8 (TPL2)-dependent MAPK1/3 activation
HDR through Homologous Recombination (HRR)
MAPK6/MAPK4 signaling
UCH proteinases
UCH proteinases
Josephin domain DUBs
Ub-specific processing proteases
Ovarian tumor domain proteases
Metalloprotease DUBs
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Major pathway of rRNA processing in the nucleolus and cytosol
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
Regulation of TP53 Activity through Methylation
Negative regulation of MET activity
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
Cyclin D associated events in G1
G2/M Checkpoints
Stabilization of p53
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Ubiquitin-dependent degradation of Cyclin D
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Downregulation of ERBB2 signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
E3 ubiquitin ligases ubiquitinate target proteins
InlB-mediated entry of Listeria monocytogenes into host cell
InlB-mediated entry of Listeria monocytogenes into host cell
InlA-mediated entry of Listeria monocytogenes into host cells
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN localization
Regulation of PTEN stability and activity
Neddylation
ER Quality Control Compartment (ERQC)
Regulation of expression of SLITs and ROBOs
Regulation of expression of SLITs and ROBOs
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH3 Activation and Transmission of Signal to the Nucleus
TICAM1-dependent activation of IRF3/IRF7
TICAM1,TRAF6-dependent induction of TAK1 complex
Interleukin-1 signaling
Peroxisomal protein import
Peroxisomal protein import
Regulation of signaling by CBL
Endosomal Sorting Complex Required For Transport (ESCRT)
Iron uptake and transport
Negative regulators of DDX58/IFIH1 signaling
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK2 mediated activation of TAK1 complex
TRAF6-mediated induction of TAK1 complex within TLR4 complex
Negative regulation of NOTCH4 signaling
Chaperone Mediated Autophagy
Late endosomal microautophagy
Response of EIF2AK4 (GCN2) to amino acid deficiency
Prevention of phagosomal-lysosomal fusion
Modulation by Mtb of host immune system
Alpha-protein kinase 1 signaling pathway
Aggrephagy
Aggrephagy
RAS processing
Pexophagy
Maturation of protein E
Maturation of protein E
Negative regulation of FLT3
FLT3 signaling by CBL mutants
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Amyloid fiber formation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Pegademase
4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
Diseases
GWAS
Deep white matter hyperintensities (
32517579
)
Multiple sclerosis (
31604244
)
Systemic lupus erythematosus (
29848360
26502338
28714469
)
Systemic sclerosis (
31672989
)
Triglyceride levels (
32203549
)
Interacting Genes
399 interacting genes:
A2M
ABI3
ABI3BP
ABL1
ABL2
ACAP1
ADA
ADAM12
ADAM15
ADRB1
ADRB2
AEBP1
AGR2
AGT
AHSG
AJUBA
ALAS2
ALOX5
AMBP
ANKRD13A
ANKRD23
ANXA2
AP4S1
APCS
APOH
APP
AR
ARHGAP17
ARHGAP32
ARHGAP35
ARID5A
ASAP1
ASAP2
AUNIP
AXL
B2M
BCAR1
BCL2A1
BCR
BLNK
BPGM
BTG1
C1orf94
C21orf58
C21orf91
CALD1
CASC3
CASP2
CBL
CBLB
CBLC
CCDC28B
CCL5
CD164
CD19
CD22
CD247
CD28
CD2AP
CD72
CDC42
CDKN1B
CFH
CHRM4
CHRND
CKS2
CLNK
CLU
COPB1
COX6A1
CPSF7
CRBN
CRK
CRKL
CSF1R
CSF3R
CSN2
CTTN
CUTA
DAB2
DAG1
DCTN1
DCTN2
DDIT4L
DDX17
DLGAP1
DNAJA3
DNAJB11
DNM1
DNM2
DOCK4
DPPA4
DRD3
DRD4
DTX1
DTX3
DVL2
E2F2
ECHS1
EFHC2
EGF
EGFR
ELK1
ENO1
EP300
EPHA2
EPHB1
EPHB2
EPHB6
EPOR
EPS15
EPS8
ERBB2
ERBB3
ERBB4
ERRFI1
ESD
ESR1
ETV6
FABP1
FASLG
FCGR2A
FCGR2B
FGFR1
FGFR3
FH
FHOD1
FLT1
FLT3
FLT4
FN1
FRS2
FRS3
FTH1
FTL
FYN
GAB1
GAB2
GAB3
GAREM1
GC
GGN
GHR
GIT1
GPANK1
GRAP2
GRB7
GSTK1
H1-0
HCLS1
HELZ
HIPK3
HNRNPC
HNRNPK
HOMEZ
HP
HRAS
HSPA5
HTT
IK
IKZF3
IL2RB
INCA1
INPP5D
IRS1
IRS2
IRS4
ITGA2B
ITGA6
ITGB4
ITIH4
ITK
JAK1
JAK2
KDR
KHDRBS1
KHDRBS2
KIAA0408
KIAA1549L
KIF3A
KIT
KPNA2
KPRP
KRT8
LAT
LAT2
LAX1
LCP2
LIME1
LMO2
LNX1
LNX2
LY6G6F
LZTS2
MAP1A
MAP2
MAP4K1
MAP4K3
MAP4K5
MAPK1
MAPK12
MAPK14
MAPK9
MAPT
MED19
MED28
MEI4
MERTK
MET
METTL27
MIA2
MICAL1
MLXIPL
MS4A2
MSI2
MST1R
MT-ATP8
MT-ND4
MTA1
MTA3
MUC1
MYG1
MYH11
MYH9
MYO18A
MYOZ1
NADK
NAP1L5
NCKIPSD
NCL
NEU3
NFYB
NGFR
NIF3L1
NKD2
NPM1
NTRK1
NUTM2F
OCRL
OLIG1
PACRGL
PAG1
PAK1
PAK2
PAK4
PBXIP1
PCDHB5
PDCD6IP
PDE4D
PDE6G
PDGFRB
PHACTR4
PHC2
PHETA1
PIK3AP1
PIK3C2B
PIK3CG
PIK3R1
PIK3R2
PIK3R3
PLCG1
PLEKHA7
PNMA5
PNRC1
POLR1D
POLR2A
POMP
PON2
PPP3CA
PRAP1
PRKAB1
PRKAR1A
PRNP
PRR22
PRR5-ARHGAP8
PRRC2A
PTK2
PTK2B
PTPN1
PTPN11
PTPN12
PTPN22
PTPN6
PTPRA
PTPRC
PTPRE
PXN
RALGPS1
RAPGEF1
RAPSN
RASA1
RBBP6
RBM33
RBP4
REL
REPS1
REPS2
RET
RHOU
RIF1
RNF10
RNF208
RPS6KA1
SELL
SF3A2
SF3B4
SH2B1
SH2B2
SH2B3
SH2D1A
SH2D4A
SH3BP2
SH3D19
SH3KBP1
SHANK3
SHB
SHBG
SHC1
SHC2
SHC3
SHC4
SHKBP1
SIGLEC7
SIT1
SKAP1
SLC1A2
SLX1A
SNRNP200
SNTA1
SOCS1
SOCS7
SOS1
SOS2
SPATA2L
SPRY1
SPRY2
SPTBN1
SRC
SS18
STAMBP
STK32C
STRADB
SYK
SYN1
SYNCRIP
SYNJ1
SYNJ2
SYP
TBC1D3B
TBC1D3G
TCEAL8
TCERG1
TEK
TF
TFG
TLE5
TNFRSF1A
TNK2
TOM1L1
TP53BP2
TP63
TRAT1
TRIB3
TRIM27
TSC2
TSPAN2
TUB
TXK
TYRO3
UBA1
UBA52
UBC
UQCC2
USP53
USP6NL
USP8
VAV1
VAV2
VAV3
VIM
VPS37C
WAS
WASF1
WASF2
WASL
WBP11
WDFY3
WDR1
WDR44
WIPF1
WIPF2
YLPM1
ZAP70
ZBTB12
ZBTB7B
ZMAT1
ZNF341
ZNF474
ZNF620
39 interacting genes:
ACVR1
ARRDC3
BMPR1B
DAZAP2
DESI1
DNAJB2
EPN2
FAM168A
FSHR
GRB2
HERC3
HGS
KHDRBS1
LAPTM5
LITAF
MAPK6
MTURN
NCK1
PLEKHB2
PLSCR4
POLI
RABGEF1
RAD23A
RNF11
SLC2A4
SMAD1
SMAD2
SMAD4
SMURF1
SQSTM1
TAX1BP1
TGFBR1
TSG101
UBQLN1
UBQLN2
USP46
USP7
VPS28
WBP2
Entrez ID
2885
7311
HPRD ID
00150
08931
Ensembl ID
ENSG00000177885
ENSG00000221983
Uniprot IDs
B0LPF3
P62993
P62987
Q3MIH3
Q7Z4P3
PDB IDs
1AZE
1BM2
1BMB
1CJ1
1FHS
1FYR
1GCQ
1GFC
1GFD
1GHU
1GRI
1IO6
1JYQ
1JYR
1JYU
1QG1
1TZE
1X0N
1ZFP
2AOA
2AOB
2H46
2H5K
2HUW
2VVK
2VWF
2W0Z
3C7I
3IMD
3IMJ
3IN7
3IN8
3KFJ
3MXC
3MXY
3N7Y
3N84
3N8M
3OV1
3OVE
3S8L
3S8N
3S8O
3WA4
4P9V
4P9Z
5CDW
6ICG
6ICH
6SDF
6VK2
6WM1
6WO2
2LJ5
2MBH
2MJB
2MUR
2N3U
2N3V
2N3W
2NBD
2NBE
2RSU
4HJK
4JIO
4P4H
4PIG
4PIH
4PIJ
4RF0
4RF1
4S1Z
4UG0
4V6X
4XKL
5AJ0
5GO7
5GO8
5GOB
5GOC
5GOD
5GOG
5GOH
5GOI
5GOJ
5GOK
5HPK
5HPL
5HPS
5HPT
5J26
5J8P
5JBV
5JBY
5LKS
5T2C
6EK0
6IP5
6IP6
6IP8
6LQM
6OLE
6OLF
6OLG
6OLI
6OLZ
6OM0
6OM7
6QZP
6XA1
6Y0G
6Y2L
6Y57
6Y6X
6Z6L
6Z6M
6Z6N
6ZM7
6ZME
6ZMI
6ZMO
Enriched GO Terms of Interacting Partners
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