FMR1 and YBX1

Data Source:
HPRD (in vivo)

		FMR1	YBX1
Description		FMRP translational regulator 1	Y-box binding protein 1
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Polysome MRNA Cap Binding Complex Chromocenter Cytoplasmic Stress Granule Postsynaptic Density Cajal Body Membrane Extrinsic Component Of Plasma Membrane Axon Dendrite Growth Cone Filopodium Tip SMN Complex Cytoplasmic Ribonucleoprotein Granule Presynaptic Membrane Polysomal Ribosome Cell Projection Neuron Projection Neuronal Cell Body Dendritic Spine Perikaryon Axon Terminus Dendritic Spine Neck Synapse Postsynaptic Membrane Perinuclear Region Of Cytoplasm Neuronal Ribonucleoprotein Granule Glial Cell Projection Presynapse Postsynapse Dendritic Filopodium Messenger Ribonucleoprotein Complex Growth Cone Filopodium Ribonucleoprotein Complex	Extracellular Region Nucleus Nucleoplasm U12-type Spliceosomal Complex Cytoplasm Cytosol Cytoplasmic Stress Granule Nuclear Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome CRD-mediated MRNA Stability Complex Histone Pre-mRNA 3'end Processing Complex Messenger Ribonucleoprotein Complex Ribonucleoprotein Complex
	Molecular Function	G-quadruplex RNA Binding Chromatin Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding Microtubule Binding Poly(U) RNA Binding Translation Repressor Activity Translation Initiation Factor Binding RNA Strand Annealing Activity Poly(G) Binding Methylated Histone Binding SiRNA Binding MiRNA Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity Ribosome Binding Ion Channel Binding Translation Regulator Activity Protein Heterodimerization Activity MRNA 5'-UTR Binding Dynein Complex Binding Sequence-specific MRNA Binding	Nucleic Acid Binding DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding MiRNA Binding GTPase Binding C5-methylcytidine-containing RNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Protein Phosphorylation Positive Regulation Of Receptor Internalization MRNA Processing Cellular Response To DNA Damage Stimulus Glutamate Receptor Signaling Pathway Nervous System Development RNA Splicing Viral Process Negative Regulation Of Translation Gene Silencing By RNA Positive Regulation Of Histone Phosphorylation Cellular Response To UV Regulation Of MRNA Stability Modulation By Host Of Viral RNA Genome Replication Positive Regulation Of Translation Negative Regulation Of Translational Initiation Regulation Of Neurotransmitter Secretion MRNA Transport Regulation Of Filopodium Assembly Positive Regulation Of Filopodium Assembly Regulation Of Gene Silencing By MiRNA Regulation Of Dendritic Spine Development Positive Regulation Of Dendritic Spine Development Cellular Response To Hydroxyurea Cellular Response To Virus Regulation Of Neuronal Action Potential Negative Regulation Of Long-term Synaptic Depression Positive Regulation Of Intracellular Transport Of Viral Material Negative Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of MRNA Catabolic Process Positive Regulation Of MRNA Binding Negative Regulation Of Synaptic Vesicle Exocytosis Positive Regulation Of Gene Silencing By MiRNA Negative Regulation Of Cytoplasmic Translation Positive Regulation Of Response To DNA Damage Stimulus	MRNA Splicing, Via Spliceosome Regulation Of Transcription, DNA-templated Notch Signaling Pathway Epidermis Development Regulation Of Gene Expression Negative Regulation Of Translation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Embryonic Morphogenesis RNA Transport TRNA Transport Positive Regulation Of Cell Division CRD-mediated MRNA Stabilization Protein Localization To Cytoplasmic Stress Granule MiRNA Transport Negative Regulation Of Cellular Senescence
Pathways			mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Noncanonical activation of NOTCH3
Drugs
Diseases		Premature ovarian failure Fragile X Syndrome, including: Fragile X Syndrome (FXS); Fragile X tremor/ataxia syndrome (FXTAS)
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 22808956) Fragile X syndrome ( 30531935)
Interacting Genes		27 interacting genes: AKAP9 ATG5 CASK CWC25 CYFIP1 CYFIP2 EFHC1 FSD2 FXR1 FXR2 INCA1 LIMS1 MEOX1 NCL NUFIP1 NUFIP2 POLR1C RANBP9 RBM14 SF3B2 SPAG5 STAU1 SUOX UBE2I WBP2NL YBX1 ZBTB42	116 interacting genes: ACTA2 AKT1 ANKRD2 APBB1 CALM1 CASP8 CSNK2A1 CTCF DUX4 FBXO33 FMR1 FUS GSK3B H1-2 HABP4 HLA-C HNRNPD HNRNPK IL7R IREB2 IRF1 JAM2 LCP2 LSM3 MAPK1 MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I MYC MYCN NFYB PCBP2 PCNA PRPF40A PURA RBBP6 RPS6KA1 RPS6KA3 SLC6A4 SMAD3 SMU1 SREK1 SRSF9 TFAP2A TP53 TRAF6 VEGFA
Entrez ID		2332	4904
HPRD ID		02398	01095
Ensembl ID		ENSG00000102081	ENSG00000065978
Uniprot IDs		Q06787	P67809
PDB IDs		2BKD 2FMR 2LA5 2QND 4OVA 4QVZ 4QW2 5DE5 5DE8 5DEA 5UWJ 5UWO	1H95 5YTS 5YTT 5YTV 5YTX 6A6L 6KTC 6KUG 6LMR 6LMS
Enriched GO Terms of Interacting Partners?
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