ICOSLG and BACE2

Data Source:
BioGRID (affinity chromatography technology)

		ICOSLG	BACE2
Description		inducible T cell costimulator ligand	beta-secretase 2
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome	Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Integral Component Of Membrane Dense Core Granule
	Molecular Function	Signaling Receptor Binding Protein Binding Identical Protein Binding	Aspartic-type Endopeptidase Activity Protein Binding
	Biological Process	Regulation Of Cytokine Production Adaptive Immune Response Defense Response Hyperosmotic Response Signal Transduction T Cell Costimulation Positive Regulation Of Activated T Cell Proliferation T Cell Activation B Cell Activation T Cell Receptor Signaling Pathway	Proteolysis Membrane Protein Ectodomain Proteolysis Peptide Hormone Processing Glucose Homeostasis Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Astrocyte Activation Amyloid-beta Metabolic Process
Pathways		Costimulation by the CD28 family
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576 29875488) Celiac disease ( 22057235 20190752) Cerebral amyloid deposition (PET imaging) ( 30361487) Crohn's disease ( 18587394 21102463) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 23128233) Left ventricular QRS voltage ( 27195777) Rheumatoid arthritis ( 30423114) Type 1 diabetes ( 25751624) Ulcerative colitis ( 21297633)	Adult body size ( 32376654) Body mass index ( 25673413) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Elevated fasting plasma glucose ( 30004843) Glycemic traits (pregnancy) ( 23903356)
Interacting Genes		1 interacting genes: ICOS	3 interacting genes: APP GGA1 GGA2
Entrez ID		23308	25825
HPRD ID		05757	05744
Ensembl ID		ENSG00000160223	ENSG00000182240
Uniprot IDs		A0N0L8 B7Z1W8 O75144	Q9Y5Z0
PDB IDs		6X4G 6X4T	2EWY 3ZKG 3ZKI 3ZKM 3ZKN 3ZKQ 3ZKS 3ZKX 3ZL7 3ZLQ 4BEL 4BFB 6JSZ 6UJ0 6UJ1
Enriched GO Terms of Interacting Partners?
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