BOP1 and KLF10

Data Source:
BioGRID (two hybrid)

		BOP1	KLF10
Description		BOP1 ribosomal biogenesis factor	Kruppel like factor 10
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Chromosome Nucleolus Preribosome, Large Subunit Precursor PeBoW Complex Ribonucleoprotein Complex	Chromatin Nucleus
	Molecular Function	RNA Binding Protein Binding Ribonucleoprotein Complex Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Ribosomal Large Subunit Assembly Cleavage In ITS2 Between 5.8S RRNA And LSU-rRNA Of Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Maturation Of LSU-rRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Cell Population Proliferation Ribosome Biogenesis Regulation Of Cell Cycle Regulation Of Signal Transduction By P53 Class Mediator	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Cell-cell Signaling Circadian Rhythm Negative Regulation Of Cell Population Proliferation Cellular Response To Starvation Bone Mineralization Somatic Stem Cell Population Maintenance Regulation Of Circadian Rhythm Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Peptide
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Dupuytren's disease ( 28886342) FEV1 ( 30804560) Lung function (FVC) ( 30804560) Type 2 diabetes ( 30297969)	Chronic lymphocytic leukemia ( 23770605) IgA nephropathy ( 26028593) Neurofibrillary tangles ( 31497858) Urate levels ( 31578528)
Interacting Genes		2 interacting genes: KLF10 PES1	17 interacting genes: BOP1 CDK2 CDK6 CRIP2 FBXW7 KAT2B LENG1 PIGC RPL14 SF3B3 SIAH1 SIN3A SNHG29 SP1 TNS1 TULP3 ZNF512B
Entrez ID		23246	7071
HPRD ID		16558	03527
Ensembl ID		ENSG00000261236	ENSG00000155090
Uniprot IDs		Q14137	Q13118
PDB IDs			2EPA
Enriched GO Terms of Interacting Partners?
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