PHLPP1 and SERPINB7

Data Source:
HPRD (in vitro)

		PHLPP1	SERPINB7
Description		PH domain and leucine rich repeat protein phosphatase 1	serpin family B member 7
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle	Extracellular Space Cytoplasm
	Molecular Function	Protein Serine/threonine Phosphatase Activity Protein Binding Metal Ion Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Regulation Of T Cell Anergy Protein Dephosphorylation Apoptotic Process Signal Transduction Entrainment Of Circadian Clock Regulation Of Apoptotic Process Regulation Of MAPK Cascade Regulation Of JNK Cascade Negative Regulation Of Protein Kinase B Signaling Regulation Of P38MAPK Cascade	Negative Regulation Of Endopeptidase Activity Positive Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Glomerular Mesangial Cell Proliferation Positive Regulation Of Platelet-derived Growth Factor Production
Pathways		Negative regulation of the PI3K/AKT network
Drugs
Diseases
GWAS		Aggressiveness in attention deficit hyperactivity disorder ( 27021288) Hip circumference adjusted for BMI ( 28552196) Plateletcrit ( 32888494)	Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Asthma ( 31361310 30929738 32296059 31619474) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Food allergy ( 29051540) Hen's egg allergy ( 29051540) Systolic blood pressure ( 29208002)
Interacting Genes		6 interacting genes: BRAP CSNK1A1 GSK3B SLC9A3R1 SUGT1 WDR48
Entrez ID		23239	8710
HPRD ID		15145	04524
Ensembl ID		ENSG00000081913	ENSG00000166396
Uniprot IDs		O60346	A8K3Q8 O75635
PDB IDs
Enriched GO Terms of Interacting Partners?
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