AKR1B1 and SHBG

Data Source:
BioGRID (two hybrid)

		AKR1B1	SHBG
Description		aldo-keto reductase family 1 member B	sex hormone binding globulin
Image
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytosol Plasma Membrane Bounded Cell Projection Cytoplasm Paranodal Junction Mast Cell Granule Schmidt-Lanterman Incisure Perinuclear Region Of Cytoplasm Extracellular Exosome Schwann Cell Microvillus	Extracellular Region Extracellular Exosome
	Molecular Function	Retinal Dehydrogenase Activity Alditol:NADP+ 1-oxidoreductase Activity Protein Binding Electron Transfer Activity Glyceraldehyde Oxidoreductase Activity Allyl-alcohol Dehydrogenase Activity NADP-retinol Dehydrogenase Activity	Steroid Binding Androgen Binding Protein Binding
	Biological Process	Retinoid Metabolic Process Tissue Homeostasis Epithelial Cell Maturation Renal Water Homeostasis Carbohydrate Metabolic Process Sorbitol Biosynthetic Process C21-steroid Hormone Biosynthetic Process Response To Water Deprivation Naphthalene Metabolic Process Electron Transport Chain Stress-activated Protein Kinase Signaling Cascade Regulation Of Urine Volume Norepinephrine Metabolic Process Retinol Metabolic Process Negative Regulation Of Apoptotic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Fructose Biosynthetic Process Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Smooth Muscle Cell Proliferation Maternal Process Involved In Female Pregnancy Cellular Hyperosmotic Salinity Response Inner Medullary Collecting Duct Development Metanephric Collecting Duct Development Response To Thyroid Hormone Cellular Response To Methylglyoxal Cellular Response To Peptide
Pathways		Pregnenolone biosynthesis Fructose biosynthesis
Drugs		Glutathione NADH Sulindac Inhibitor Idd 384 alpha-D-glucose 6-phosphate Alrestatin Fidarestat (S,R)-fidarestat Zenarestat Tolrestat N-Acetylalanine Sorbinil IDD552 Cacodylic acid Nicotinamide adenine dinucleotide phosphate Citric acid Ranirestat Pimagedine QR-333 Exisulind (2-{[(4-BROMO-2-FLUOROBENZYL)AMINO]CARBONYL}-5-CHLOROPHENOXY)ACETIC ACID (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID Lidorestat {3-[(5-CHLORO-1,3-BENZOTHIAZOL-2-YL)METHYL]-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL}ACETIC ACID 3-[5-(3-nitrophenyl)thiophen-2-yl]propanoic acid CP-744809 (R)-minalrestat 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID {4-[(CARBOXYMETHOXY)CARBONYL]-3,3-DIOXIDO-1-OXONAPHTHO[1,2-D]ISOTHIAZOL-2(1H)-YL}ACETIC ACID 2-(CARBOXYMETHYL)-1-OXO-1,2-DIHYDRONAPHTHO[1,2-D]ISOTHIAZOLE-4-CARBOXYLIC ACID 3,3-DIOXIDE IDD594 {[5-(5-nitro-2-furyl)-1,3,4-oxadiazol-2-yl]thio}acetic acid 2-(3-((4,5,7-trifluorobenzo[d]thiazol-2-yl)methyl)-1H-pyrrolo[2,3-b]pyridin-1-yl)acetic acid Zopolrestat	Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases
GWAS		Blood protein levels ( 30072576 29875488) White matter growth ( 29682794)	Androgen levels ( 22936694) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266)
Interacting Genes		5 interacting genes: APLNR CDC42 EFCAB11 SHBG SMAD1	62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 C9orf24 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A
Entrez ID		231	6462
HPRD ID		00071	01646
Ensembl ID		ENSG00000085662	ENSG00000129214
Uniprot IDs		A0A024R7A8 P15121	B0FWH2 B0FWH8 B4DYU0 I3L145 P04278
PDB IDs		1ABN 1ADS 1AZ1 1AZ2 1EF3 1EL3 1IEI 1MAR 1PWL 1PWM 1T40 1T41 1US0 1X96 1X97 1X98 1XGD 1Z3N 1Z89 1Z8A 2ACQ 2ACR 2ACS 2ACU 2AGT 2DUX 2DUZ 2DV0 2F2K 2FZ8 2FZ9 2FZB 2FZD 2HV5 2HVN 2HVO 2I16 2I17 2IKG 2IKH 2IKI 2IKJ 2INE 2INZ 2IPW 2IQ0 2IQD 2IS7 2ISF 2J8T 2NVC 2NVD 2PD5 2PD9 2PDB 2PDC 2PDF 2PDG 2PDH 2PDI 2PDJ 2PDK 2PDL 2PDM 2PDN 2PDP 2PDQ 2PDU 2PDW 2PDX 2PDY 2PEV 2PF8 2PFH 2PZN 2QXW 2R24 3BCJ 3DN5 3G5E 3GHR 3GHS 3GHT 3GHU 3LBO 3LD5 3LEN 3LEP 3LQG 3LQL 3LZ3 3LZ5 3M0I 3M4H 3M64 3MB9 3MC5 3ONB 3ONC 3P2V 3Q65 3Q67 3RX2 3RX3 3RX4 3S3G 3T42 3U2C 3V35 3V36 4GCA 4GQ0 4IGS 4JIR 4LAU 4LAZ 4LB3 4LB4 4LBR 4LBS 4NKC 4PR4 4PRR 4PRT 4PUU 4PUW 4Q7B 4QBX 4QR6 4QX4 4QXI 4RPQ 4XZH 4XZI 4YS1 4YU1 5HA7 5OU0 5OUJ 5OUK 6F7R 6F81 6F82 6F84 6F8O 6SYW 6T27	1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB
Enriched GO Terms of Interacting Partners?
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