ZBTB43 and MCM10

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ZBTB43	MCM10
Description		zinc finger and BTB domain containing 43	minichromosome maintenance 10 replication initiation factor
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Nucleus Nucleoplasm Nucleolus Replication Fork Protection Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding Enzyme Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Cellular Response To DNA Damage Stimulus Cell Population Proliferation
Pathways			Activation of ATR in response to replication stress Activation of the pre-replicative complex
Drugs
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Eyebrow thickness ( 26926045)	Nicotine dependence symptom count ( 25555482)
Interacting Genes		27 interacting genes: AEN AP1M1 ARR3 ARRB1 BDP1 CCDC13 CDKL3 CIB3 DDX6 DIP2A ELOA2 FAM161A LMO1 LMO3 LMO4 LNX1 MCM10 MORF4L1 MORF4L2 PSMD3 SYT6 TCEA2 TRAF2 ZBTB24 ZNF250 ZNF417 ZNF587	38 interacting genes: APP CALCOCO2 CCDC85B CCND1 CCND3 CDC45 CDC5L CDC6 CDC7 CDK6 CDKN1A CDKN2A CEP70 CEP72 DAPK1 DPPA2 GOLGA2 HAUS1 HOOK2 IKBKG KLHL40 KRT15 MCM2 MCM3 MCM6 MCM7 NINL ORC2 ORC3 ORC4 PICK1 RECQL4 TNIP1 TRIM37 UBAC1 YWHAE ZBTB43 ZBTB8A
Entrez ID		23099	55388
HPRD ID		08346	11297
Ensembl ID		ENSG00000169155	ENSG00000065328
Uniprot IDs		O43298	Q7L590
PDB IDs		2CSH
Enriched GO Terms of Interacting Partners?
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