PDZD2 and PKP4

Data Source:
HPRD (in vitro, in vivo)

		PDZD2	PKP4
Description		PDZ domain containing 2	plakophilin 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Plasma Membrane Cell-cell Junction Centriolar Satellite Intracellular Membrane-bounded Organelle	Spindle Pole Cornified Envelope Nucleus Cytoplasm Cytoskeleton Plasma Membrane Cell-cell Junction Adherens Junction Cytoplasmic Side Of Plasma Membrane Cell Junction Desmosome Midbody Cell-cell Contact Zone Perinuclear Region Of Cytoplasm Spindle Midzone Mitotic Spindle
	Molecular Function		Protein Binding Cadherin Binding
	Biological Process	Cell Adhesion	Cell-cell Junction Assembly Cell-cell Signaling Regulation Of Cell Adhesion Keratinization Positive Regulation Of Cytokinesis Positive Regulation Of GTPase Activity Cornification Cell-cell Adhesion
Pathways			Keratinization Formation of the cornified envelope
Drugs
Diseases
GWAS		Cerebrospinal fluid t-tau levels in Alzheimer's disease dementia ( 29274321) Chronic obstructive pulmonary disease ( 29394082) Corpus callosum central volume ( 31530798) Height ( 28552196) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intracranial aneurysm ( 29531279) Myocardial infarction ( 26708285) Obesity-related traits ( 23251661) Optic disc size ( 31809533) Renal cell carcinoma ( 23184150) Response to serotonin reuptake inhibitors in major depressive disorder (plasma drug and metabolite levels) ( 24528284) Reticulocyte fraction of red cells ( 32888494) Self-reported childhood asthma in adult smokers ( 30373671) Vertical cup-disc ratio ( 31798171 28073927) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Working memory ( 31598132)	Borderline personality disorder ( 28632202) Obesity-related traits ( 23251661) Restless legs syndrome ( 29029846)
Interacting Genes		5 interacting genes: ADGRB1 CST3 CTNND2 NRXN1 PKP4	19 interacting genes: ATPAF2 CDH1 CDH2 CDH5 DSC3 DSP ERBIN GABARAP GOLGA2 LNX1 LZTS2 MINK1 OSGEP PAXIP1 PDZD2 PGAM1 PSEN1 TRIM23 UBASH3B
Entrez ID		23037	8502
HPRD ID		10142	05043
Ensembl ID		ENSG00000133401	ENSG00000144283
Uniprot IDs		A0A024RE15 O15018	Q99569
PDB IDs
Enriched GO Terms of Interacting Partners?
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